NeuroMab™ Anti-Amyloid Beta 1-40 BBB Shuttle Antibody, Clone 9TL

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Clone Number

9TL

Applications

In Vitro; ELISA

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

Amyloid Beta 1-40

Official Name

Amyloid Beta 1-40

Full Name

Amyloid beta

Alternative Names

APP; Aβ; Abeta; Amyloid β

Product Pictures

Figure 1 shows the epitope mapping of antibody 9TL by peptide competition.

A(31-ao peptides were immobilized on SA chips. Monoclonal antibody 2289 and 9TL Fab fragments (50 nM each), each mixed with 10 gM of each peptide (amino acids 28-40, 1-40, 1-28, 28- 42, 22-35, 1-16, 1-43, 33-40, 1-38, or 17-40 AP) or no peptide and flowed onto the chip. Antibody Fab fragments immobilized API-40 peptide were measured.

Publications