NeuroMab™ Anti-Amyloid Beta 1-5 BBB Shuttle Antibody,Clone NR1486P
- Host Species:
- Humanized
- Species Reactivity:
- Human
- Applications:
- WB; ELISA; In Vitro; Cyt
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
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Figure 1 illustrates the Aβ binding properties of 3D6, chimeric 3D6 and 10D5.
Figure 1A is a graph depicting the binding of Aβ to chimeric 3D6 (PK1614) compared to murine 3D6.
Figure 1 illustrates the Aβ binding properties of 3D6, chimeric 3D6 and 10D5.
Figure 1 is a graph depicting the competition of biotinylated 3D6 with unlabeled 3D6, PK1614 and 10D5 for Aβ binding.
Figure 2 illustrates the Aβ binding properties of chimeric 3D6 and humanized 3D6.
Figure 2A depicts the results of an ELISA measuring the binding of humanized 3D6v1 and chimeric 3D6 to aggregated Aβ.
Figure 2 illustrates the Aβ binding properties of chimeric 3D6 and humanized 3D6.
Figure 2B depicts the results of an ELISA measuring the binding of humanized 3D6v1 and humanized 3D6v2 to aggregated Aβ.
Figure 3 is a graph quantifying the binding of humanized 3D6 and chimeric 3D6 to Aβ plaques from PDAPP mouse brain sections.
Figure 4 is a graph showing the results of a competitive binding assay testing the ability of humanized 3D6 versions 1 and 2, chimeric 3D6, murine 3D6 and 10D5 to compete with murine 3D6 for binding to Aβ.
Figure 5 illustrates an ex vivo phagocytosis assay testing the ability of humanized 3D6v2, chimeric 3D6, and human IgG to mediate Aβ uptake by microglia.
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