NeuroMab™ Anti-ANO5/TMEM16E BBB Shuttle Antibody, Clone N421A/85

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-ANO5 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1-299 (cytoplasmic N-terminus) of human ANO5 (also known as Anoctamin-5, Gnathodiaphyseal dysplasia 1 protein, Transmembrane protein 16E, GDD1, TMEM16E and RGD1564265, accession number Q75V66)
Rat: 80% identity (228/283 amino acids identical)
Mouse: 77% identity (226/292 amino acids identical)
<45% identity with ANO6/TMEM16F

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N421A/85

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with ANO6/TMEM16F

Research Areas

Ion channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

ANO5

Official Name

ANO5

Full Name

ANO5/TMEM16E

Alternative Names

ANO5

Uniprot ID

Q75V66

Product Pictures

Fig. 1 Immunoblot against extracts of COS cells transiently transfected with untagged ANO5/TMEM16E, GFPtagged ANO6/TMEM16F or untagged Kv2.1 plasmid probed with N421A/85 (left) or N86/38 (right) TC supe.

Publications