Product
NeuroMab™ Anti-ANO6/TMEM16F BBB Shuttle Antibody, Clone N429/19
[CAT#: NRZP-0423-ZP26]
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- WB; IHC; ICC
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-ANO6 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 1-294 (cytoplasmic N-terminus) of human ANO6 (also known as Anoctamin-6, Small-conductance calcium-activated nonselective cation channel, SCAN channel, Transmembrane protein 16F, Tmem16f and rCG_50511, accession number Q4KMQ2)
Mouse: 86% identity (256/296 amino acids identical)
Rat: 81% identity (257/317 amino acids identical)
<45% identity with ANO5/TMEM16E
Mouse: 86% identity (256/296 amino acids identical)
Rat: 81% identity (257/317 amino acids identical)
<45% identity with ANO5/TMEM16E
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Human; Mouse; Rat
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
N429/19
Applications
WB; IHC; ICC
Application Notes
Does not cross-react with ANO5/TMEM16E
Research Areas
Ion channels
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
ANO6
Official Name
ANO6
Full Name
ANO6/TMEM16F
Alternative Names
ANO6
Uniprot ID
Q4KMQ2
Product Pictures
IB
Fig. 1 Immunoblot against lysates of wild-type (WT) and ANO6/TMEM16F knockout (KO) mouse embryonic fibroblasts probed with N429/19 TC supe.
IB
Fig. 2 Adult rat brain membrane immunoblot.
IHC
Fig. 3 Adult rat whole brain immunohistochemistry.
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
