NeuroMab™ Anti-GABA-A-R-Alpha6 BBB Shuttle Antibody, Clone N229A/32

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-GABA A Receptor Alpha 6 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 325-420 (last cytoplasmic domain before extracellular C-terminus) of mouse GABA-A-R-Alpha6 (also known as Gamma-aminobutyric acid receptor subunit alpha-6, GABA(A) receptor subunit alpha-6 and Gabra6, accession number P16305)
Rat: 91% identity (88/96 amino acids identical)
Human: 73% identity (71/96 amino acids identical)
<40% identity with GABA-A-R-Alpha4 and other GABA-A receptors

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Mouse; Rat

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N229A/32

Applications

WB; IHC; ICC

Application Notes

Does not react with GABA-A-R-Alpha4

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

GABA A Receptor Alpha 6

Official Name

GABRA6

Full Name

GABA(A)R, Alpha6

Alternative Names

GABRA6; gamma-aminobutyric acid type A receptor alpha6 subunit; gamma-aminobutyric acid type A receptor subunit alpha6

Uniprot ID

P16305

Product Pictures

Fig. 1 Immunoblot against extracts of COS cells transiently transfected with DsRed-tagged GABAARAlpha4, Flag-tagged GABAARAlpha6 or untagged Kv2.1 plasmid probed with N229A/32 (left), Mouse anti-Flag (middle) or N398A/34 (right) TC supe.