Product
NeuroMab™ Anti-Galanin BBB Shuttle Antibody,Clone NR1699P
[CAT#: NRZP-1022-ZP3377]
- Host Species:
- Humanized
- Species Reactivity:
- Human
- Applications:
- WB; ELISA; FC; Inhib; Block; Cyt; In Vitro
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Humanized
Clone Number
NR1699P
Applications
WB; ELISA; FC; Inhib; Block; Cyt; In Vitro
Relevant Diseases
Alzheimer's Disease; Epilepsy; Depression
Product Properties
Storage
Store at -20°C. Do not aliquot the antibody.
Research Use Only
For research use only
Target
Target
Galanin
Official Name
GAL
Full Name
Galanin
Alternative Names
GAL; GAL-GMAP; GALN; GLNN; GMAP; ETL8; galanin and GMAP prepropeptide
Product Pictures
FuncS
Figure 1 shows the results of the GALR2 filtration assay.
Membrane preparations from A9 cells engineered to overexpress GALR2 were incubated with 125I-labeled human galanin and mouse anti-galanin hybridoma supernatants and harvested onto GF/B Unifilter plates. Twenty-one hybridomas were able to inhibit the binding of human galanin to GALR2.
FuncS
Figure 2 shows the results of the affinity assay.
FuncS
Figure 3 shows that administration of anti-galanin antibodies reduces tumor growth in established tumors.
Publications
Publications (0)
Neural Antibodies
Kits
Neural Cell Lines
For Research Use Only. Not For Clinical Use.
