NeuroMab™ Anti-Galanin BBB Shuttle Antibody,Clone NR1701P
- Host Species:
- Humanized
- Species Reactivity:
- Human
- Applications:
- In Vitro; In Vivo
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Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
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Figure 1 shows the results of the affinity assay.
Hybridoma supernatants from confluent cultures were serially diluted, preincubated with 125 I-labeled human galanin, and precipitated with an excess of protein G sepharose. Monoclonal antibodies produced by hybridomas are ranked according to affinity. The following seven mAbs were rated as high affinity: 2H9, 1G12, 5B4, 1D7, 4B3, 2F8, and 1A1. The following mAbs were rated as low affinity: 4G5, 2B11, 4C10, 1C1, 1D6, 4A10, 2F9, 5C5, and 2E11.
Figure 2 shows that administration of anti-galanin antibodies reduces tumor growth in established tumors.
Athymic nude mice injected with 5 million COLO-677 cells were administered 200 μg of anti-galanin IgG or vehicle approximately 10-14 days after the tumor volume reached approximately 50-100 mm3.
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