Product
NeuroMab™ Anti-Histone H3.3 BBB Shuttle Antibody, Clone N158/28
[CAT#: NRZP-0423-ZP166]
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- ELISA; DB; ICC; WB; IHC
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-H3F3A BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Synthetic peptide amino acids 83-93 (LRFQSAAIGAL) of rat Histone H3.3 (also known as H3.3a/b and H3f3a/b, accession number P84245) Mouse: 100% identity (11/11 amino acids identical)
Human: 100% identity (11/11 amino acids identical)
>70% identity with Histone H3.2 and H3.1 (8/11 amino acids identical)
Human: 100% identity (11/11 amino acids identical)
>70% identity with Histone H3.2 and H3.1 (8/11 amino acids identical)
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Human; Mouse; Rat
Clonality
Monoclonal
Isotype
IgG1
Clone Number
N158/28
Applications
ELISA; DB; ICC; WB; IHC
Application Notes
Does not cross-react with Histone H3.1
Research Areas
Epigenetics
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
H3F3A
Official Name
H3-3A
Full Name
Histone H3.3
Alternative Names
H3-3A; H3.3A; H3F3; H3 histone; family 3A; H3 histone family member 3A; H3.3 histone A; H3F3A; H3-3B
Uniprot ID
P84245
Product Pictures
IHC
Fig. 1 Adult rat hippocampus immunohistochemistry (with antigen retrieval via pepsin pretreatment).
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
