NeuroMab™ Anti-IL-6 BBB Shuttle Antibody, Clone NR85P
- Host Species:
- Humanized
- Species Reactivity:
- Human
- Applications:
- In Vitro; In Vivo; Antagonist
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
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Figure 1 depicts mean plasma CRP concentrations following a single intravenous injection in patients with advanced cancer. Ab1 (ALD518) was infused at 80, 160 or 320 mg (n=8).
Figure 2 depicts mean serum CRP levels in rheumatoid arthritis patients with an inadequate response to methotrexate following administration of 80, 160, or 320 mg of Ab1(ALD518).
Figure 3 shows that Ab1 increased mean hemoglobin concentration (g/dL) by 80, 160 and 320 mg after 12 weeks of administration in NSCLC patients compared to placebo.
Figure 4 depicts Ab1 increasing mean albumin concentrations at 80, 160 and 320 mg in NSCLC patients.
Figure 5 graphically illustrates the mean change in SF-36 composite score at week 12 in a phase II clinical trial of ALD518 administered to patients with active RA.
Figure 6 depicts the relationship between WHO oral mucositis grade and cumulative IMRT (Gy): Three patients received ALD518 160 mg intravenously at weeks 0 and 4.
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