NeuroMab™ Anti-IL-6 BBB Shuttle Antibody, Clone NR86P
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- In Vitro; In Vivo; Inhib; Antagonist
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Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
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Figure 1 is a graph illustrating experimental results of IVT administration of an anti-IL-6 antibody in a rat CNV model.
Anti-VEGF antibody was administered as a positive control and the negative control was vehicle alone, p = 0.0054 on Day 15 and p = 0.0005 on Day 22 for anti-IL-6 vs. vehicle control.
Figure 2 is a graph illustrating the results of a binding experiment testing the ability of the murine 64 antibody to inhibit the binding of IL-6/IL-6R to gp130.
Figure 3 is a graph illustrating an experiment in which the ability of 020 to block IL-6 signaling was tested in the absence of excess soluble IL-6Ra.
Experiments were performed in HEK-Blue-IL-6 cells with 0.2 ng/mL IL-6 and 2pg/mL IL6Ra.
Figure 4 is a graph illustrating an experiment in which the ability of 020 to block IL-6 signaling was tested in the absence of excess soluble IL-6Ra.
Experiments were performed in HEK-Blue-IL-6 cells with 0.2 ng/mL IL-6 and 2pg/mL IL6Ra.
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