NeuroMab™ Anti-KIR2DL1; KIR2DL2; KIR2DL3 BBB Shuttle Antibody, Clone 1-4F1

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Human

Clone Number

1-4F1

Applications

FC; ELISA; Neut

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

KIR2DL1; KIR2DL2; KIR2DL3

Product Pictures

FuncS

Figure 1 depicts the induction of NK-mediated killing by cross-reactive murine (DF200 and NKVSF1 (Pan2D)) and human (1-7F9, 1-4F1, 1-6F5, and 1-6F1) mAbs,

FuncS

Figure 2 depicts the induction of NK-mediated killing by the same antibodies as in Figure 5 . mAb induced (reconstituted) killing of KIR2DL1-expressing NK cells (YTS 30 KIR2DL1) by B-EBV cells expressing endogenous HLA-Cw4. E/T ratio = 2.30 pg/ml mAb.

Publications