Product
NeuroMab™ Anti-Kv9.1 potassium channel BBB Shuttle Antibody, Clone N461/19
[CAT#: NRZP-0423-ZP235]
- Species Reactivity:
- Mouse; Rat
- Applications:
- WB; IHC; ICC
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-KCNS1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 1-186 (cytoplasmic N-terminus) of mouse Kv9.1 (also known as Potassium voltage-gated channel subfamily S member 1, Delayed-rectifier K(+) channel alpha subunit 1 and Kcns1, accession number O35173)
Rat: 98% identity (183/186 amino acids identical)
Human: 90% identity (168/186 amino acids identical)
<50% identity with Kv9.1/Kcns1 and Kv9.3/Kcns3
Rat: 98% identity (183/186 amino acids identical)
Human: 90% identity (168/186 amino acids identical)
<50% identity with Kv9.1/Kcns1 and Kv9.3/Kcns3
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Mouse; Rat
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
N461/19
Applications
WB; IHC; ICC
Research Areas
K+ channels
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
KCNS1
Official Name
KCNS1
Full Name
Kv9.1 K+ channel
Alternative Names
KCNS1; KV9.1
Uniprot ID
O35173
Product Pictures
IB
Fig. 1 Adult rat brain membrane immunoblot.
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
