NeuroMab™ Anti-TRPML3/Mucolipin-3 BBB Shuttle Antibody, Clone N268/19

[CAT#: NRZP-0423-ZP446]

Species Reactivity:: Human; Mouse; Rat

Applications:: WB; IHC; ICC

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Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-TRPML3 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Synthetic peptide amino acids 269-285 (CKDWHVSGSIQKNTHYM, extracellular N-terminus) of human TRPML3 (also known as Mucolipin-3 and MCOLN3, accession number Q8TDD5)
Mouse: 100% identity (17/17 amino acids identical)
Rat: 100% identity (17/17 amino acids identical)
<50% identity with TRPML2

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

N268/19

Applications

WB; IHC; ICC

Research Areas

Trp channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

TRPML3

Official Name

MCOLN3

Full Name

TRPML3/Mucolipin-3

Alternative Names

MCOLN3; TRP-ML3; TRPML3; mucolipin 3

Uniprot ID

Q8TDD5

Product Pictures

Fig. 1 Tissue and transfected cell immunoblot: extracts of rat brain membranes (RBM) and of COS cells transiently transfected with HA-tagged mouse and human TRPML3 (mTRPML3 and hTRPML3) or untagged Kv2.1 plasmid and probed with N268/19 (left) and K89/34 (right) TC supe.

Publications