Mouse Anti-ITGB4 Monoclonal Antibody (CBP2870)

Product Overview

Description

Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated alpha and beta subunits. Integrin beta-4 is predominantly expressed in squamous epithelial cells, endothelial cells, immature thymocytes, Schwann cells, and fibroblasts of the peripheral nervous system (PMID: 28084395). Integrin beta-4 pairs with alpha-6, and the heterodimeric integrin alpha-6/beta-4 is a receptor for laminin. Integrin alpha-6/beta-4 plays a critical structural role in the hemidesmosome of epithelial cells, and also plays a role in the invasive and metastatic phenotype of various cancers.

Expression Host

Mammalian cells

Immunogen

Integrin Beta 4 fusion protein Ag17395

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP2870

Applications

WB; ELISA

Application Notes

WB : 1:500-1:1000

Research Areas

Metabolism

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

1000 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

ITGB4

Official Name

ITGB4

Full Name

Integrin Beta 4

Alternative Names

CD104;
CD104 antigen;
gp150;
Integrin beta 4 subunit;
Integrin beta-4;
ITB4_HUMAN;
ITG B4;

Gene ID

3691(Human); 192897(Mouse)

Uniprot ID

P16144(Human); A2A863(Mouse)

References

1. Ma, B., Zhang, L., Zou, Y., He, R., Wu, Q., Han, C., & Zhang, B. (2019). Reciprocal regulation of integrin β4 and KLF4 promotes gliomagenesis through maintaining cancer stem cell traits. Journal of Experimental & Clinical Cancer Research, 38(1), 1-17. 2. Li, Y., Chen, Y., Qiu, C., Ma, X., Lei, K., Cai, G.,... & Liu, J. (2019). 17-allylamino-17-demethoxygeldanamycin impeded chemotherapy through antioxidant activation via reducing reactive oxygen species-induced cell death. Journal of cellular biochemistry, 120(2), 1560-1576. 3. Xu, J., & Lu, W. (2020). FAM83A exerts tumor‑suppressive roles in cervical cancer by regulating integrins. International journal of oncology, 57(2), 509-521.

Publications