Mouse Anti-TNF Monoclonal Antibody (CBP3002)

Product Overview

Description

TNF is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme (TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, INS resistance, and cancer.

Expression Host

Mammalian cells

Immunogen

Human TNF Alpha protein HZ-1014

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP3002

Applications

Neut; ELISA

Research Areas

GPCR

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

1000 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

TNF

Official Name

TNF

Full Name

Tumor necrosis factor (TNF superfamily, member 2)

Alternative Names

Cachectin; DIF; TNF; TNF a; TNF alpha; TNFA; TNF-a; TNFSF2; TNFα; Tumor necrosis factor

Gene ID

7124(Human); 21926(Mouse)

Uniprot ID

P01375(Human); P06804(Mouse)

References

1. Deng, J., Feng, J., Liu, T., Lu, X., Wang, W., Liu, N.,... & Zhou, Y. (2018). Beraprost sodium preconditioning prevents inflammation, apoptosis, and autophagy during hepatic ischemia-reperfusion injury in mice via the P38 and JNK pathways. Drug Design, Development and Therapy, 12, 4067. 2. Chen, S., Zeng, X., Zong, W., Wang, X., Chen, L., Zhou, L.,... & Hu, K. (2019). Aucubin alleviates seizures activity in Li-Pilocarpine-Induced epileptic mice: involvement of inhibition of neuroinflammation and regulation of neurotransmission. Neurochemical research, 44(2), 472-484.

Publications