Product
NeuroMab™ Anti-ADAM17 Antibody, Clone D8 (CBP8582)
[CAT#: NRP-0422-P927]
- Host Species:
- Human
- Species Reactivity:
- Human
- Applications:
- Inhib; In Vitro
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
ADAM17 is a well-validated target, inhibitors against its active/catalytic site have failed clinical trials due to lack of specificity/efficacy and toxicity issues. The antibody provides a novel intervention strategy based on targeting the substrate-recognition domain of ADAM17 - which is essential for ADAM17 activity. By targeting this domain of ADAM17 instead of the catalytic site, the adverse side effects associated with prior attempts to target ADAM 17 for therapeutic applications may be avoided.
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Human
Clone Number
CBP8582
Applications
Inhib; In Vitro
Product Properties
Preservatives
BSA Free
Concentration
1mg/mL
Endotoxin Level
Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg
Low Endotoxin < 1 EU/mg
Shipping
Gel Packs
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Research Use Only
For research use only
Target
Target
ADAM17
Official Name
ADAM17
Full Name
ADAM Metallopeptidase Domain 17
Alternative Names
ADAM Metallopeptidase Domain 17; Tumor Necrosis Factor; Alpha; Converting Enzyme; Snake Venom-Like Protease; TNF-Alpha Convertase; EC 3.4.24.86; TACE; CSVP; Disintegrin And Metalloproteinase Domain-Containing Protein 17; ADAM Metallopeptidase Domain 18;
Publications
Publications (0)
Neural Antibodies
Neural Genes
Neural Cell Lines
For Research Use Only. Not For Clinical Use.
