NeuroMab™ Anti-BACE1 Antibody, Clone 2H8
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- Inhib; WB; In Vitro; In Vivo
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Low Endotoxin < 1 EU/mg
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Figure 2 shows the induction of a mouse TREM2-dependent luciferase reporter gene in a cell-based assay.
Cells were either untreated (NT) or treated with soluble full-length anti-TREM2 antibodies 1H7, 2F6, 2H8, 3A7, 3B10, 7E5, 7F8, 8F8, and 11H5. Antibody mlgG1 is an isotype negative control. Cells treated with PMA/ionomycin represent a positive control. Results are represented as folded backgrounds (indicated by dashed lines).
Figure 4 shows the concentration of CCL4 (pg/ml) in the peritoneal cavity after injection of control (CTR) or TREM2 antibodies 7E5 and 8F8 in combination with LPS.
Figure 3 shows the induction of a mouse TREM2-dependent luciferase reporter gene in a cell-based assay. Cells were either untreated (NT) or treated with soluble full-length anti-TREM2 antibodies 1H7, 2F6, 2H8, 3A7, 3B10, 7E5, 7F8, 8F8, and 11H5.
Figure 1 shows wild-type (WT) bone marrow-derived mouse macrophages treated with 100 nM soluble full-length anti-TREM2 antibodies 1H7, 2F6, 2H8, 3A7, 7E5, 7F8, and 8F8 or a commercial antibody (R&D Cat #F7E57291).
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