Mouse Anti-Human BACE1 Monoclonal Antibody (CBP3719)

Product Overview

Description

β-Secretase 1 (BACE1) is a new type of membrane-bound aspartyl protease that can cleave β-amyloid precursor protein (βAPP) to generate the N-terminus of the Aβ domain. The membrane-bound C-terminal fragment produced by β secretase cleavage is then cleaved by γ secretase, resulting in the production and secretion of Aβ. The amyloidogenic peptide Aβ is the main factor in the etiology of Alzheimer's disease.

Immunogen

Recombinant human BACE1 protein.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b, κ

Clone Number

CBP3719

Applications

Application Notes

WB (1.0-5.0 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Alexa Fluor 594; Alexa Fluor 488; Alexa Fluor 498; Alexa Fluor 647; Alexa Fluor 700; APC; APC/Cyanine 7; APC/Fire 750; Biotin; Brilliant Violet 421; Brilliant Violet 510; Brilliant Violet 570; Brilliant Violet 570; Brilliant Violet 605; Brilliant Violet 650; Brilliant Violet 711; Brilliant Violet 750; Brilliant Violet 785; FITC; HRP; PE; Pacific Blue; PE/Cyanine 5; PE/Cyanine 7; PerCP; Spark YG 570

Product Properties

Form

Liquid

Formulation

50% glycerol in aqueous buffered solutions with preservatives.

Concentration

0.5 mg/mL

Purification

Affinity Chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon receipt, the antibody solution should be stored undiluted at-20°C, and protected from prolonged exposure to light.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

BACE1

Official Name

BACE1

Full Name

Beta-Secretase 1

Alternative Names

Beta-Secretase 1; Membrane-Associated Aspartic Protease 2; Beta-Site APP Cleaving Enzyme 1; Beta-Site APP-Cleaving Enzyme; Aspartyl Protease 2; EC 3.4.23.46; Memapsin-2; Asp 2; BACE; ASP2;

Gene ID

23621 (Human); 23821 (Mouse); 29392 (Rat)

Uniprot ID

P56817 (Human); P56818 (Mouse); P56819 (Rat)

References

1. Vassar R, et al. 2014. J. Neurochem. 130:4-28.
2. Kandalepas PC, Vassar R. 2014. Curr. Alzheimers Res. 11:441-9.
3. Kandalepas PC, Vassar R. 2012. J. Neurochem. 120(Suppl. 1):55-61.
4. Gruninger-Leitch F, et al. 2002. J. Biol. Chem. 277:4687-93.
5. Koelsch G. 2017. Molecules. 22(10): E1723.

Publications