NeuroMab™ Anti-EPHA2 BBB Shuttle Antibody, Clone NR267P
- Host Species:
- Humanized
- Species Reactivity:
- Human
- Applications:
- In Vitro; Inhib; Cyt
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Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
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Figure 1 Kinetic analysis of EphA2 phosphorylation in MDA-MB-231 cells. WT wild-type untreated cells; MW molecular weight marker; P-EphA2 phosphorylated Epha2
Figure 2A Inhibition of EphA2 phosphorylation after EphrinA1/Fc induced NCI-H1299 cells (5A) and MDA-MB-231 cells (5B), respectively; WT wild-type untreated cells; MW molecular weight markers; P-EphA2 phosphorylation Normalized EphA2.
Figure 2B EphrinA1/Fc induced inhibition of EphA2 phosphorylation in NCI-H1299 cells (5A) and MDA-MB-231 cells (5B), respectively; WT wild-type untreated cells; MW molecular weight markers; P-EphA2 phosphorylation Normalized EphA2.
Figure 3 Cytotoxic activity of hu2H11R35R74-PEG4-Mal-DM4 compared to hu2H11-PEG4-Mal-DM4 (small filled circles DAR=6.7; large filled circles DAR=7.0).
Figure 4 Time graph (semi-logarithmic scale) representing the mean plasma concentration of hu2H11-SPDB-DM4 following a single intravenous dose of 20 mg/kg immunoconjugate in HGS to male CD-1 mice (n=2 ). Total concentrations of human IgG (solid diamonds) and conjugated moieties (open squares) are shown.
Figure 5 Time plot (semi-logarithmic scale) representing mean plasma concentrations of hu2H11R35R74-PEG4-NHAc-DM4 (n=2) after single dose intravenous administration of 20 mg/kg immunoconjugate in HGS to male CD- 1 Mouse. Total concentrations of human IgG (solid diamonds) and conjugated moieties (open squares) are shown.
Figure 6A Bar graph representation of PK parameters of hu2H11R35R74-PEG4-NHAc-DM4 under various DARs, exposure to (AUC(0-inf); Figure 9A) and clearance (Cl; Figure 9B) of several ADCs DAR function following a single intravenous dose of 20 mg/kg of HGS immunoconjugate to male CD-1 mice (n=4).
Figure 6B PK parameters of hu2H11R35R74-PEG4-NHAc-DM4 in various DARs, exposed to (AUC(0-inf); Figure 9A) and cleared (Cl; Figure 9B) for several ADCs. DAR function after a single intravenous dose of 20 mg/kg of HGS immunoconjugate in male CD-1 mice (n=4).
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