NeuroMab™ Anti-EPHA2 BBB Shuttle Antibody,Clone NR3829P
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- ADCC; CDC; In Vitro; In Vivo; Inhib
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Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
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Figure 1 shows the presence or absence of ADCC activity of anti-EPHA2 antibodies against various cell lines.
BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a graph showing ADCC activity against MDA-MB-231 cells.
Figure 2 shows the CDC activity of anti-EPHA2 antibodies against various cells.
Figure 3 is a graph showing the antitumor activity of SH348-1 in mice transplanted with MDA-MB-231 cells.
Figure 4 is a diagram showing the binding activity of SH348-1 and EPHA2 extracellular domain polypeptide.
Figure 5 is a graph showing the ligand-binding inhibitory activity of SH348-1, SH357-1, and Ab96-1.
Figure 6 is a graph showing that SH348-1 and SH357-1 have ephrin-A1-dependent phosphorylation activity to inhibit EPHA2 tyrosine residues.
Figure 7 is a graph showing the reactivity of SH357-1 to EPHA2 deletion mutants.
Figure 8 is a graph showing the binding activity between hSH357-1-T1 and EPHA2 extracellular domain polypeptide.
Figure 9 is a graph showing the competitive inhibitory activity of hSH357-1-T1 and hSH357-1-T3 on SH357-1 antigen binding.
Figure 10 is a graph showing the activity of hSH357-1-T1 or hSH357-1-T3 to inhibit ephrin-A1-dependent phosphorylation of EPHA2 tyrosine residues.
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