NeuroMab™ Anti-IGF1R Antibody, Clone I-3466

Product Overview

Description

The antibody is a novel antibody which is capable of binding specifically to the human insulin-like growth factor I receptor (IGF-IR).

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

I-3466

Applications

FC; Inhib; In Vivo; In Vitro

Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

>95% by SDS PAGE or HPLC

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only

Target

IGF1R

Official Name

IGF1R

Full Name

insulin-like growth factor 1 (IGF-1) receptor

Alternative Names

IGF1R; CD221; IGFIR; IGFR; JTK13; insulin like growth factor 1 receptor; Insulin-like growth factor 1;IGF-1R

Gene ID

3480(Human); 16001(Mouse); 25718(Rat)

Uniprot ID

P08069(Human); Q60751(Mouse); P24062(Rat)

Product Pictures

FuncS

Figure 1 [125I]-IGF-1 competes with monoclonal antibody I-3466 for binding to IGF-IR.

Specific [ 125 I]-IGF-1 binding (%) is plotted on a semi-log graph as a function of ligand concentration. Specific binding values are the mean of experiments performed in triplicate.

FuncS

Figure 2 [125I]-IGF-2 competes with mAb I-3466 for IGF-IR binding.

FuncS

Figure 3 Effect of I-3466 Mab on IGF2-induced phosphorylation of IGF-IR β chain in MCF-7 cells.

FuncS

Figure 4 In vivo activity of I-3466 in DU145 xenograft tumor model.

SPR

Figure 5 Sensorgrams of IgG1 humanized I-3466/hIGF-IR-ECD complexes in the association and dissociation phases of five different concentrations of hIGF-IR-ECD.