NeuroMab™ Anti-IGF1R Antibody (NRP-0422-P1427)
Functional antibody against Human, Cynomolgus Monkey IGF1R
- Host Species:
- Mouse
- Species Reactivity:
- Human; Cynomolgus Monkey
- Applications:
- ELISA; In Vitro; In Vivo; Inhib
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Low Endotoxin < 1 EU/mg
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Research Use Only
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Figure 5 Sensorgrams of IgG1 humanized I-3466/hIGF-IR-ECD complexes in the association and dissociation phases of five different concentrations of hIGF-IR-ECD.
Figure 6 Effect of I-3466 antibody on IGF1-induced growth of MCF-7 in vitro.
Figure 1 Tumor volume of Co1o205 colon adenocarcinoma xenografts treated with vehicle, Ang2-h38c2, IGF1R antibody (2.12.1.fx) or MAC-2 (IP, 1x/wk).
Data are presented as mean and standard error for n=10/group on days 0-28 (n=10 for all groups after day 28). *: P <0.05, IGF1R antibody (2.12.1.fx) 10 mg/kg vs. MAC-2 10 mg/kg.
Figure 2 Relative IGF1R expression levels in lysates prepared from excised and frozen tumors.
Figure 3 Co1o205 colon adenocarcinoma xenografts with vehicle, Ang2-h38c2 (10 mg/kg), IGF1R antibody (2.12.1.fx) (10 mg/kg) or MAC-2 (1, 3 or 10 mg/kg ) process. kg).
Figure 4 Co1o205 colon adenocarcinoma xenografts using vehicle, Ang2-h38c2 (10 mg/kg), IGF1R antibodies (2.12.1.fx and 2.13.2) (10 mg/kg), MAC-2 (1,3 or 10 mg/kg) or Ang2-h38c2 (10 mg/kg) in combination with 2.12.2.fx or 2.13.2 (10 mg/kg). All data are described as mean and standard error of n=10/group.
Figure 5 Tumor volume of MDA-MB-435 melanoma after weekly treatment with vehicle or MAC-2 (IP, weekly).
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