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NeuroMab™ Anti-IL1RAP Antibody,Clone NR2461P
Functional antibody against Human IL1RAP
- Host Species:
- Humanized
- Species Reactivity:
- Human
- Applications:
- ELISA; Inhib; Block; ADCC
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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SPECIFIC INQUIRY
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Species Reactivity
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Host Species
Clone Number
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Relevant Diseases
Conjugation
Formulation
Preservatives
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Purification
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Endotoxin Level
Low Endotoxin < 1 EU/mg
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Research Use Only
Figure 1 Binding of exemplary antibodies to human IL-1RAP in an indirect ELISA. The exemplary antibody CAN04 of the present invention is known to have the highest affinity for human IL-IRAP.
![](https://img.creative-biolabs.com/neuros/productImages/NRP-0523-P858-1.png)
Figure 2 Binding of an exemplary antibody of the invention (CAN04) to human CML and AML cells.
![](https://img.creative-biolabs.com/neuros/productImages/NRP-0523-P858-2.png)
Figure 3 Ability of exemplary antibody CAN04 to block IL-1α signaling.
![](https://img.creative-biolabs.com/neuros/productImages/NRP-0523-P858-3.png)
Figure 4 CAN04 in IF.
Combined with CAN04-AF488 conjugated antibody (green) and incubated for 2 hours on ice, or 2 hours at 37 ° C, or with CAN04-AF488 conjugated antibody (green) Confocal image (one optical section is about 0.9 [mu] m thick) representing LAMA cells incubated for 16 hours. Clearly visible antibodies bound to the cell membrane of the majority of cells are observed after 2 hours of incubation on ice (" Ice 2h "). After incubation with CAN04-AF488 conjugated antibody (green) for 2 hours at 37 ° C, in addition to membrane binding, the antibody began to enter the cell (internalization) and localized in the cell substrate.
![](https://img.creative-biolabs.com/neuros/productImages/NRP-0523-P858-4.png)
Figure 5 The effect of low fucose and Fc mutations on ADCC activity was determined using SKMEL5 cells.
![](https://img.creative-biolabs.com/neuros/productImages/NRP-0523-P858-5.png)
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