NeuroMab™ Anti-Kv1.4 potassium channel (extracellular) BBB Shuttle Antibody, Clone L71/5

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-KCNA4 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 336-370 (DDRDLIMALSAGGHSRLLNDTSAPHLENSGHTIFN, extracellular S1-S2 linker) of rat Kv1.4 (also known as Potassium voltage-gated channel subfamily A member 4, HPCN2, Voltage-gated K(+) channel HuKII or HBK4 or HK1, Kcna4, KCNA4L, RCK4, RHK1 and RK3, accession number P15385)
Mouse: 100% identity (35/35 amino acids identical)
Human: 91% identity (32/35 amino acids identical)
<50% identity with other Kv1 potassium channel subunits

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse

Clonality

Monoclonal

Isotype

IgG1

Clone Number

L71/5

Applications

WB; IHC; ICC

Research Areas

K+ channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

KCNA4

Official Name

KCNA4

Full Name

Kv1.4 K+ channel (extracellular)

Alternative Names

KCNA4; HBK4; HK1; HPCN2; HUKII; KCNA4L; KCNA8; KV1.4; PCN2; potassium voltage-gated channel subfamily A member 4; MCIDDS

Uniprot ID

P15385

Product Pictures

Fig. 1 Tissue and transfected cell immunoblot: extracts of crude adult rat brain membrane (RBM) and COS cells transiently transfected with untagged Kv1.4 or Kv2.1 plasmid and probed with L71/5 (left), K13/31 (middle) or K89/34 (right) TC supe.

Publications