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Creative Biolabs

NeuroMab™ Anti-Kv1.4 potassium channel subunit BBB Shuttle Antibody, Clone K13/31

[CAT#: NRZP-0423-ZP206]

Species Reactivity:
Rat; Mouse; Human
Applications:
WB; IHC; IP; ICC

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Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-KCNA4 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Synthetic peptide 13-37 (NSHMPYGYAAQARARERERLAHSR, intracellular Nterminus) of rat Kv1.4 (also known as Potassium voltage-gated channel subfamily A member 4, HPCN2, Voltage-gated K(+) channel HuKII or HBK4 or HK1, Kcna4, KCNA4L, RCK4, RHK1 and RK3, accession number P15385)
Mouse: 100% identity (24/24 amino acids identical)
Human: 100% identity (24/24 amino acids identical)
<50% identity with other Kv1 potassium channel subunits

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse; Human

Clonality

Monoclonal

Isotype

IgG1

Clone Number

K13/31

Applications

WB; IHC; IP; ICC

Application Notes

No cross-reactivity against Kv1.1, Kv1.2, Kv1.3, Kv1.5 or Kv1.6

Research Areas

K+ channels

Conjugation

Unconjugated
Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.
Target

Target

KCNA4

Official Name

KCNA4

Full Name

Kv1.4 K+ channel

Alternative Names

KCNA4; HBK4; HK1; HPCN2; HUKII; KCNA4L; KCNA8; KV1.4; PCN2; potassium voltage-gated channel subfamily A member 4; MCIDDS

Uniprot ID

P15385
Product Pictures
IB

Fig. 1 Adult rat brain membrane immunoblot.

IHC

Fig. 2 Adult rat hippocampus immunohistochemistry.

IB

Fig. 3 Immunoblot on membrane fractions of whole rat (RBM) and mouse (MBM) brain and from human cerebral cortex [HBM(Cx)] and hippocampus [HBM(H)].

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