NeuroMab™ Anti-PDGFRB BBB Shuttle Antibody, Clone NR185P

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Human

Clone Number

NR185P

Applications

Inhib; Block; In Vitro; In Vivo

Relevant Diseases

Tumor

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

PDGFRB

Official Name

PDGFRB

Full Name

Platelet-derived growth factor receptor beta

Alternative Names

PDGFRB; CD140B; IBGC4; IMF1; JTK12; PDGFR; PDGFR-1; PDGFR1; KOGS; PENTT; platelet derived growth factor receptor beta

Product Pictures

Block

Figure 1 is a histogram showing the results of a PDGF ligand blocking assay in which PDGFR-β was captured on the biosensor surface and PDGF ligands (BB, DD or AB) were blocked after treatment with various anti-PDGFR-β antibodies. Apply to surface. Results are displayed in RU.

FuncS

Figure 2 is a matrix showing the results of an antibody cross-competition assay in which a first anti-PDGFR-β antibody (mAb#1) was applied to a PDGFR-β-coated sensor tip and then treated with a second anti-PDGFR - Beta antibody (mAb#2).

Publications