NeuroMab™ Anti-S100B BBB Shuttle Antibody,Clone NR357P

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Clone Number

NR357P

Applications

Neut; Block; In Vitro; In Vivo

Relevant Diseases

Alzheimer's Disease; Parkinson's Disease; Amyotrophic Lateral Sclerosis; Ischemic Stroke; Epilepsy

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

S100Beta

Official Name

S100B

Full Name

S100 calcium-binding protein B

Alternative Names

S-100 protein beta chain; S-100 protein subunit beta; S100 calcium-binding protein B

Product Pictures

ELISA

Fig.1 Dose-response curves for engineered antibodies.

Indirect ELISAs were used to detect muBL356(lC8) in PBS and serum. The data are expressed as the mean percent binding ± the SEM (n=3). The shift in the dose response curve indicates that quantitative data can be obtained if control and experimental samples contain equivalent concentrations of serum.

FuncS

Fig.2 In vivo pharmacodynamics/target engagement for engineered antibodies.

Representative micrographs of brains sections from 6 month old PSAPP mice treated with a single dose of engineered antibody (BL356) or placebo/control for 7 days. Sections were processed using S100B + TLR4 primary antibodies (brown; solid arrows) and counterstained with hematoxylin to visualize nuclei (blue; dashed arrows). Bars = 50 μm.

Publications