Top 3 Popular Neurological Research-Related Markers

The prevalence of neurological disorders is on the rise as the global population increases and average life expectancy extends. A study indicates that more than a third of the world's population, i.e., over 3 billion people, will be affected by neurological disorders by 2021. The widespread nature of neurological disorders is expected to increase the demand for their research, detection and treatment.

The field of neurobiology is currently experiencing a high growth phase, with studies of the brain and nervous system often requiring the targeting of neural stem cells, neurons, astrocytes, oligodendrocytes, and microglia for exploration. In this article, we have compiled a list of common neurodegenerative diseases and neuronal cell research markers to aid in neuro-related scientific research.

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Neurological Disease-based Assay	Creative Biolabs presents an extensive selection of cutting-edge in vitro assay services focused on neurological diseases. These assays provide a profound understanding of disease mechanisms at the cellular level, aid in drug discovery, and pave the way for personalized therapeutic strategies.
Neuron Assay	At Creative Biolabs, our expert scientists provide custom assay readouts in addition to standard viability and survival tests and neurite outgrowth.
Biomarker Analysis	At Creative Biolabs, we can achieve professional and first-class biomarker analysis by using validated approaches and cutting-edge technologies. In addition to the above services, we can also design, improve or develop new analysis solutions according to your research direction.

Neurodegenerative Disease Research Marker

Neurodegenerative diseases are progressive loss of neuronal structure and function, including neuronal death and glial cell homeostasis, which can lead to cognitive disorders such as dementia. These include Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD), etc.; neurodegenerative diseases are characterized by complex pathogenic mechanisms including protein aggregation, neuroinflammation, and mitochondrial dysfunction; they severely affect physical mobility, memory, and emotional control, threatening human health and daily life.

Representative Targets	Target Description	Antibody Products
APP	APP encoding amyloid precursor protein is a transmembrane glycoprotein that plays a major role in the pathogenesis of AD. Under normal conditions, A-secretase cleaves APP to produce the C83 carboxy-terminal fragment and soluble APP. In disease states, B-secretase and γ-secretase sequentially and abnormally cleave APP, releasing Aβ40 and Aβ42, leading to neuronal cell death.	NAB-08-PZ100 NAB-0720-Z6320 NAB-0720-Z6348 NAB20121048LS
Tau	Tau protein is a microtubule-binding protein that is widely distributed in nerve cells of the nervous system and is an important component used to stabilize the microtubules that serve as the skeleton of nerve cells.	NAB-0720-Z4212 NAB-0720-Z4215 NAB-0720-Z4221 NAB-0720-Z4234
APOE	APOE is the main apolipoprotein of celiac particles and binds to high-density lipoprotein (HDL) and a variety of cellular receptors, of which APOE4 has been shown to have a close relationship with the development of AD in recent findings.	NAB-08-PZ112 NAB2007FY799 NAB-0321-R0593 NAB-0321-R0601
PSEN1	PSEN1 is a transmembrane protein located between the endoplasmic reticulum and the Golgi apparatus and is a major component of the γ-secretase complex. PSEN1 is one of the major causative genes of Alzheimer's disease associated with the development of early-onset familial Alzheimer's disease (FAD).	NAB-08-PZ1040 NAB-0720-Z6675 NRP-0322-P1507 NRP-0422-P2033

Representative Targets	Target Description	Antibody Products
LRRK2	The LRRK2 gene is a member of the leucine-rich repeat kinase family. Mutations in LRRK2 have been associated with the development of Parkinson's disease.	NAB-08-PZ735 NAB2007FY514 NAB-0720-Z5585
SNCA	SNCA has a molecular weight of 14 kDa and consists of 140 amino acids.SNCA is highly expressed in brain cells and is mainly located at the presynaptic site, which is critical for intercellular signaling.SNCA was one of the first genes found to be associated with PD.	NAB-0720-Z5596 NAB210537SL
CNTFR	CNTFR is a receptor protein that binds ciliary neurotrophic factor (CNTF) to regulate the growth and function of nerve cells. CNTFR is mainly found on the surface of nerve cells in the central nervous system, peripheral nervous system and other organs.	NAB-0720-Z6883 NAB-2103-P131
DDC	DDC catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to produce dopamine and L-5-hydroxytryptophan to produce serotonin. These enzymatic reactions represent key steps in the biosynthesis of neurotransmitters and are essential for the normal function of the central nervous system. DDC inhibitors are used clinically, usually co-administered with L-DOPA, for the treatment of PD.	NAB-0720-Z2320 NAB-0720-Z2322

Representative Targets	Target Description	Antibody
HTT	Huntingtonin, a protein encoded by the HTT gene, is implicated in the repair of neurological damage and has an important role in embryonic development. Structural mutations in HTT are the etiology of HD.	NAB2105193SL NAB2105197SL

Neural Stem Cell Markers

Neural stem cells (NSCs), derived from pluripotent stem cells in the central nervous system, possess the ability for lifelong self-renewal and can differentiate into various types of cells in the nervous system. It is the first step of neurodevelopment for embryonic stem cells or induced pluripotent stem cells to develop into neural stem cells. NSCs express important markers such as the transcription factors SOX1, SOX2, PAX6, and Nestin.

Representative Targets	Target Description	Antibody
SOX1	SOX1 is involved in triggering early neurogenesis and maintaining primitive neurons in an undifferentiated state. SOX1 is one of the genes that regulates the survival and differentiation of neural stem cells. The SOX1 gene has been shown to regulate the survival of dopaminergic neurons in the brain and reduce the rate of neurodegeneration.	NAB-0720-Z354 NAB-0720-Z622 NAB-BA-P051
SOX2	SOX2 is a key transcription factor that maintains the self-renewal properties of pluripotent stem cells and primitive neural stem cells.	NAB2005ZP209 NAB-0720-Z258 NAB-0720-Z4586
PAX6	PAX6 is a neural ectodermal marker during early neural development. In addition, PAX6 gene plays important roles in several biological processes, including embryonic development, tumorigenesis, and regulation of neural precursor cell proliferation.	NAB-0720-Z265 NAB-08-PZ986
PAX3	PAX3 is a transcription factor that regulates cell proliferation, migration and apoptosis, and is involved in neurodevelopment and myogenesis, in addition the PAX3 gene has been closely associated with a variety of tumorigenesis.	NAB2005ZP167 NAB-0720-Z625
Nestin	Nestin, a type VI intermediate filament protein, was first identified as a marker for neural stem cells and is expressed during early development of the CNS, disappearing when the NSC differentiates into mature neurons or glial cells.	NAB2005ZP122 NAB-0720-Z437
FOXG1	FOXG1, a member of the forkhead protein transcription factor family, is a very upstream transcription factor in neurodevelopment and is involved in the regulation of numerous neurodevelopmental events, regulating different developmental processes at different developmental time points.	NAB-0720-Z4657 NAB-0720-Z4763
GAP43	GAP43 is a neuronal membrane protein that is involved in both the development and plasticity of neuronal cells and plays a key role in the repair of nerve injury.	NAB-0720-Z3397 NAB-0720-Z3448

Neuronal Markers

Neuron is the basic structural and functional unit of the nervous system. Neurons communicate through synapses to transmit neural signals in the central nervous system and peripheral transmission. Normally neuronal nuclear protein (NeuN), MAP2 and β3-Tubulin can be used as common markers of neurons.

Representative Targets	Target Description	Antibody
NeuN	NeuN is localized to the nucleus and is a protein expressed only in post-mitotic neurons and not in neural progenitor cells, oligodendrocytes, astrocytes, and glial cells.	NAB20101935CR NRZP-0522-ZP122
NEFL	NEFL, a type of neurofilament protein, is a highly conserved cytoskeletal protein that is mainly distributed in mature neurons and myelinated cells, and is an important component in the composition of nerve fibers as well as in maintaining their stability.	NAB-0421-R0295 NAB-0421-R0296
MAP2	MAP2 is an abundant neuronal cytoskeletal protein that binds to and stabilizes microtubules with microtubule proteins, and plays an important role at different times during the developmental formation and regeneration of the nervous system. MAP2 is frequently used as a dendritic marker and is distributed in neuronal cell bodies and dendrites, but not in axons.	NAB-0720-Z447 NAB-0720-Z456 NAB-0720-Z552
Beta3-tubulin	B3-Tubulin (TUBB3) is a major component of microtubules in neurons, which is highly expressed during embryonic and postnatal development and plays a key role in proper axon guidance, maturation and maintenance.	NRZP-0722-ZP455
PSD95	PSD95 is significantly expressed in the central nervous system and is associated with receptors and the cytoskeleton as a synaptic protein belonging to the membrane-associated guanylate kinase (MAGUKS) family of proteins found predominantly within mature excitatory glutamatergic synapses.	NAB-0720-Z3407 NAB-0720-Z3409 NAB-0720-Z3410
CHAT	Acetylcholine acetyltransferase (ChAT), the hallmark enzyme of cholinergic neurons, is synthesized in neuronal cells in vivo and is found only in the cytoplasm of cholinergic neurons. Choline acetyltransferase, catalyzes the reversible synthesis of ACh from acetyl coenzyme A and choline at cholinergic synapses.	NAB-0720-Z2224 NAB2007FY282 NAB-0720-Z2227
TH	Tyrosine hydroxylase (TH), a precursor of dopamine, is an enzyme that converts L-tyrosine to L-3,4-dihydroxyphenylalanine (L-DO-PA), a necessary and rate-limiting step in the formation of dopamine and other catecholamines.	NAB-0720-Z2327 NAB-0720-Z2329
OTX2	OTX2 is a transcription factor expressed in photoreceptors and bipolar cells, and reduced protein levels lead to structural alterations in the retina retinal pigment epithelium defects, neuronal degeneration, and vision loss.	NAB2005ZP164 NAB-0720-Z1625

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Top 3 Popular Neurological Research-Related Markers

Neurodegenerative Disease Research Marker

Neural Stem Cell Markers

Neuronal Markers

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