Parkinson's Disease (PD) Model based In Vitro Assay Services

Parkinson's disease (PD) is a neurodegenerative disease pathologically characterized by the loss of dopaminergic neurons in the substantia nigra and proteinaceous amyloid fibrils composed mostly of α-synuclein, called Lewy pathology. These accumulations of alpha-synuclein appear to spread from one neuron to the next. As the number of Lewy bodies increases in the brain and in the nervous system in the body, the symptoms of PD worsen. At Creative Biolabs, we are dedicated to supporting a range of PD research and therapeutic developments. We offer a comprehensive range of in vitro, in vivo and ex vivo assays tailored to meet your specific needs. Our standard and customizable models enable efficient screening of potential therapeutic compounds. Additionally, we provide detailed project reports to facilitate the advancement of your PD research.

Available In Vitro Models

We provide a comprehensive range ofin vitro models that faithfully recapitulate key aspects of PD pathology.

Fig.1 Generation and characterization of iPSC-derived astrocytes from PD patients. ICC images show astrocytes from two Ctrl iPSC lines and three PD iPSC lines that express CD44, GFAP, S100β, and GLT1, but not TUJ1, MAP2, or NG2.¹

Available PD In Vitro Services

Creative Biolabs offers a wide range of in vitro assays that enable researchers to better understand PD progression and evaluate optimized treatments for PD.

Creative Biolabs offers PD in vitro modeling and assays to assist you speed up your PD research. Please contact us for further information so that you can make better decisions sooner.

References

1. di Domenico, Angelique et al. "Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's Disease." Stem cell reports vol. 12,2 (2019): 213-229. Distributed under Open Access license CC BY 4.0, without modification.