Parkinson's Disease (PD) Model based In Vitro Assay Services
Parkinson's disease (PD) is a neurodegenerative disease pathologically characterized by the loss of dopaminergic neurons in the substantia nigra and proteinaceous amyloid fibrils composed mostly of α-synuclein, called Lewy pathology. These accumulations of alpha-synuclein appear to spread from one neuron to the next. As the number of Lewy bodies increases in the brain and in the nervous system in the body, the symptoms of PD worsen. At Creative Biolabs, we are dedicated to supporting a range of PD research and therapeutic developments. We offer a comprehensive range of in vitro, in vivo and ex vivo assays tailored to meet your specific needs. Our standard and customizable models enable efficient screening of potential therapeutic compounds. Additionally, we provide detailed project reports to facilitate the advancement of your PD research.
Available In Vitro Models
We provide a comprehensive range ofin vitro models that faithfully recapitulate key aspects of PD pathology.
Fig.1 Generation and characterization of iPSC-derived astrocytes from PD patients. ICC images show astrocytes from two Ctrl iPSC lines and three PD iPSC lines that express CD44, GFAP, S100β, and GLT1, but not TUJ1, MAP2, or NG2.1
Cell models | Details |
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Induced pluripotent stem cells (iPSCs) |
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In vitro primary culture |
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Organotypic cultures |
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Cell lines |
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Available PD In Vitro Services
Creative Biolabs offers a wide range of in vitro assays that enable researchers to better understand PD progression and evaluate optimized treatments for PD.
Alpha-Synuclein Aggregation Assay | Microglia Activation Assay |
MPP+ Neuronal Cell Death Assay | GBA Mutation Assay |
α-Synuclein Degrader Compound Screen Assay |
Creative Biolabs offers PD in vitro modeling and assays to assist you speed up your PD research. Please contact us for further information so that you can make better decisions sooner.
References
- di Domenico, Angelique et al. "Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's Disease." Stem cell reports vol. 12,2 (2019): 213-229. Distributed under Open Access license CC BY 4.0, without modification.
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