Parkinson's Disease (PD) In Vitro Assay Services

Creative Biolabs is committed to providing a range of PD in vitro assay services to meet your requirements in research and therapeutic development.

Cellular Models for PD Pathway Analysis

Our Parkinson's Disease (PD) In Vitro Assay Service offers an array of well-established cellular models that faithfully recapitulate key aspects of PD pathology. These models include dopaminergic neuronal cell lines, primary midbrain cultures, and induced pluripotent stem cell (iPSC)-derived neurons.

iPSCs-Derived Neurons

Our service harnesses the power of iPSC technology to generate patient-specific neuronal models, allowing researchers to dissect the underlying genetic factors and aberrant cellular pathways contributing to PD. By reprogramming somatic cells into pluripotent stem cells and differentiating them into dopamine-producing neurons, we provide a platform for studying the disease's etiology and testing potential therapeutic compounds.

α-Synuclein Overexpression Models

α-Synuclein aggregation is a hallmark of PD. Through sophisticated gene editing techniques, we engineer cell lines with controlled α-Synuclein overexpression, facilitating investigations into the protein's role in neuronal dysfunction and toxic aggregation. This model aids in elucidating the cascade of events triggered by α-Synuclein, potentially leading to the development of novel disease-modifying interventions.

PD In Vitro Assay Service at Creative Biolabs

Creative Biolabs provides a full range of in vitro assays that enable researchers to have a better understanding of the PD progression and to evaluate optimized therapy against PD according to different mechanisms of action.

Assays	Measurements
Alpha-Synuclein Aggregation Assay is considered involved in PD progression by affecting cell homeostasis and neural death.	Measurements of aggregation kinetics, morphology of aggregates, and the effect of various factors or compounds on aggregation.
Microglia Activation Assay aims to measure changes in microglia morphology, phenotype, and secretory profile in response to various stimuli.	Measurements of changes in morphology, gene expression profiles, protein levels, and functional responses of microglia upon activation.
MPP+ Neuronal Cell Death Assay involves exposing cultured neuronal cells to MPP+ and assessing the resulting cell death through various methods.	Measurements of cell viability, mitochondrial function, oxidative stress markers, and changes in gene and protein expression.
GBA Mutation Assay aims to identify specific mutations or sequence variations in the GBA gene that are associated with PD.	Identify mutations or sequence variations within the GBA gene.
Mitophagy Assay provides insights into autophagy activity, lysosomal function, and their roles in Parkinson's disease pathology.	LC3 Conversion Assay, p62/SQSTM1 Assay, GFP-LC3 Fluorescence Assay, Autophagy Flux Assay, Autophagic Substrates Assay, TFEB Translocation Assay:
The dopamine Release Assay is designed to study the dysfunction of dopamine-producing neurons in PD research.	Dopamine release dynamics, neurotransmitter analysis

There are multiple complex pathways involved in PD. Potential therapeutic approaches targeting different mechanisms of action are therefore demanded. Creative Biolabs also offers validated and high-throughput screening and imaging phenotypic PD in vitro assays that provide quantitative data allowing researchers worldwide to assess and predict the efficacy of therapies against several mechanisms of action comprehensively and efficiently.

If you have the intention to find out more about PD in vitro assay services, please don't hesitate to contact us.

For Research Use Only. Not For Clinical Use.

Related Section

Alpha-Synuclein Aggregation Assay

Microglia Activation Assay

MPP+ Neuronal Cell Death Assay

GBA Mutation Assay

α-Synuclein Degrader Compound Screening Assay

In Vitro Services