Epilepsy In Vitro Disease Models

Epilepsy is a cerebral dysfunction characterized by sudden, abnormally high-frequency discharges of local lesions of the brain and spread to surrounding tissues, accompanied by transient motor, sensory, conscious, and autonomic abnormalities. In addition to the physical impact of seizures, epilepsy may also cause significant psychosocial impairment in patients, affecting their daily life activities and increasing the likelihood of developing psychiatric comorbidities. Thus, epilepsy is associated with an increased mortality rate and reduced life expectancy. In recent years, the pathogenesis of epilepsy and the development of new drugs have become important research directions for many neuroscientists, Creative Biolabs provides excellent in vitro models for this research.

Table 1 Different types of death are caused by epilepsy.

Our Epilepsy In Vitro Disease Models

Models are practical tools for neurological disease research. The in vitro techniques from Creative Biolabs can save time and resources and minimize the ethical requirements. In vitro models of epileptiform activity can mimic the state of chronic epileptic tissue and some phenomenological aspects of human drug-resistant epilepsy. At Creative Biolabs, we provide epileptic in vitro models to clients worldwide to support related research projects.

• Neuronal models of epilepsy

Our technicians have successfully modeled epileptic neurons by stimulating neurons with excitatory neurotoxin, providing an excellent platform for the study of refractory epilepsy.

• Neural stem cells and epilepsy

With the application of stem cell technology in neuroscience research, Creative Biolabs has successfully established epileptic models through patient-specific induced pluripotent stem (iPS) cells to support your epilepsy research in vitro.

• Brain slice models of epilepsy

At Creative Biolabs, we can provide our partners with two types of brain slice models of epilepsy, a model of brain tissue slices in experimental animals and a model of slices of lesions surgically removed from patients with epilepsy. These sections can maintain an epileptiform lesion for approximately one month for relevant clinical trials. Please do not hesitate to contact us directly for more details.

Applications of Epileptic In Vitro Models

The epileptic models provided by Creative Biolabs allow you to explore the pathogenesis of epilepsy in vitro and to dynamically monitor the changes of multiple substances during the disease.

Fig.1 Applications of epileptic in vitro models.

The establishment of in vitro models completed by Creative Biolabs eliminates interference factors such as blood-brain barrier and metabolism and provided a platform for the study of epilepsy. We are willing to share our professional knowledge and experience for free, you can contact us for more information.