Epilepsy In Vitro Assay
In Vitro assays play a vital role in studying epilepsy by providing a controlled environment to investigate various aspects of the disease. Creative Biolabs, a leading company in the field of neuroscience research, offers a comprehensive range of Epilepsy In Vitro Assays, to facilitate advancements in epilepsy research.
Our Epilepsy Assay Models
At Creative Biolabs, we offer a variety of In Vitro assay models to mimic different aspects of epilepsy pathology. These models allow researchers to explore different cellular and molecular mechanisms involved in the disease progression. Some of our commonly used In Vitro assay models include:
Primary Neuronal Cultures
Primary neuronal cultures provide a physiologically relevant system to investigate epileptic mechanisms. These cultures can be derived from different brain regions, such as the hippocampus or cortex, and are maintained In Vitro to study network activity, excitability, and synaptic plasticity associated with epilepsy.
Induced Pluripotent Stem Cell (iPSC)-Derived Neurons
iPSC-derived neurons offer a unique opportunity to study epilepsy using patient-specific cells. By reprogramming somatic cells, such as skin fibroblasts, into pluripotent stem cells, researchers can differentiate them into neurons that carry the genetic background of individuals with epilepsy.
Organotypic Brain Slices
Organotypic brain slices provide an ex vivo model that maintains the cellular architecture and functional connectivity of the brain. These slices can be prepared from different brain regions and allow for the investigation of epileptic phenomena, such as interictal activity, seizure initiation, and propagation.
3D Brain Organoids
Brain organoids, derived from pluripotent stem cells, represent a more advanced model for epilepsy research. These 3D structures mimic the complexity of the human brain and allow for the study of cellular interactions, network formation, and the development of epileptic activity.
Our Epilepsy Assays
Our Epilepsy In Vitro assays allow researchers to investigate the cellular and molecular mechanisms of epilepsy, identify potential therapeutic targets, and evaluate the efficacy of new drugs. To gain comprehensive insights into epileptic mechanisms, it is crucial to select appropriate readouts that capture relevant aspects of the disease. Our various readout options for Epilepsy In Vitro Assays, including:
Our assays incorporate state-of-the-art electrophysiological techniques, such as patch-clamp recordings and multi-electrode array (MEA) systems. These methods enable the measurement of neuronal activity, including action potentials, synaptic transmission, and network oscillations.
Calcium imaging is a powerful tool for monitoring changes in intracellular calcium levels, which are closely associated with neuronal excitability and synaptic activity. Our assays utilize advanced calcium imaging techniques to visualize and quantify calcium dynamics in epileptic conditions.
This assay involves the preparation of thin brain slices, typically from the hippocampus, a brain region commonly associated with epilepsy. The slices are then maintained in an oxygenated artificial cerebrospinal fluid solution, allowing researchers to study the cellular and network activity that leads to epileptic seizures.
This includes the measurement of neurotransmitters, cytokines, growth factors, and other relevant biomolecules involved in epileptic processes. These analyses provide valuable insights into the molecular pathways underlying epilepsy.
Options for Collaborating with Creative Biolabs
Order epilepsy assay models for use in your lab
If you are interested in ordering epilepsy assay models and perform the assay in your lab, we offer a convenient and flexible supply of epilepsy research cell models. Please contact firstname.lastname@example.org for price and availability information.
Outsource your experiments to us
We offer a dependable and efficient service that involves collaborative experiment design to meet your specific needs. Please contact us today to explore the possibilities of collaborating with our organization.
|Rat Primary Neurons
|Mouse Primary Neurons
|iNeu™ Neuron, Astrocyte, Microglia Co-culture Kit
|iNeu™ Human iPSC-derived Motor Neurons
|iNeu™ Human iPSC-derived Dopaminergic Neurons
|iNeu™ Human iPSC-derived Cortical Neurons
|iNeu™ Human iPSC-derived Sensory Neurons
|Human iPSC-derived Neural Forebrain Organoids
|Human iPSC-derived Neural Midbrain Organoids
|Human iPSC-Derived Neural Stem Cells - Epilepsy Patient