Fragile X Syndrome In Vitro Assay Service
As a leading neurobiology CRO, we offer a cutting-edge in vitro fragile X syndrome (FXS) testing service platform. Designed to streamline your research, our platform leverages the latest scientific advancements and multi-dimensional analysis technologies. From fundamental research to high-throughput drug screening, we provide comprehensive solutions to propel your FXS studies forward. Creative Biolabs provides a comprehensive suite of advanced in vitro, in vivo, and ex vivo assays, enabling researchers to precisely investigate the complex mechanisms driving FXS pathogenesis.
Available In Vitro Models
Fig.1 Representative images of immunostaining for FMRP-WT and FMRP-KO cells at day 25.1
Cell models | Details |
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Primary Neuron Culture Model |
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Patient-derived Fibroblast Model |
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Slice Electrophysiology Model |
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Available FXS In Vitro Services
We offer a comprehensive in vitro testing platform designed to fully support Fragile X Syndrome (FXS) drug development. This platform integrates high-throughput screening, molecular mechanism analysis, and cell model validation. Key features include:
- Compound Screening and Validation
Using human FXS fibroblasts and iPSC-derived neurons to evaluate compounds targeting the MMP-9/ECM pathway and their effects on synaptic plasticity and cognition.
- Gene Therapy Strategy Validation
Utilizing in vitro models to validate gene activation technologies (e.g., 5-azadeoxycytidine) for FMR1 gene demethylation and mRNA/protein recovery.
- Protein Function Studies
Providing high-purity recombinant FMRP for binding activity analysis (e.g., semaphorin 3F mRNA) and target mechanism analysis.
- Synaptic Phenotype Analysis
Employing high-content imaging to quantify synaptic formation and functional abnormalities, suitable for FXS, autism, and Rett syndrome studies.
For further information regarding the products and services provided, project-specific consultation, and pricing, please submit an inquiry here.
Reference
- Brighi, Carlo, et al. "Novel fragile X syndrome 2D and 3D brain models based on human isogenic FMRP-KO iPSCs." Cell Death & Disease 12.5 (2021): 498. Distributed under Open Access license CC BY 4.0, without modification.
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