Astrocyte related Assay Services

Advances in imaging and molecular labeling technologies are enabling researchers to more accurately detect and quantify the functional status of astrocytes. The role of astrocyte assays covers a wide range of aspects, from neural signaling and memory formation to metabolic regulation and pathological responses, providing important support for a deep understanding of brain function and the development of new therapeutic strategies. At Creative Biolabs, all astrocyte assays can be performed on primary mouse astrocytes (wild-type and disease models), human primary astrocytes, and human iPSC-derived astrocytes. To learn more about our products and services, submit a project inquiry, or request a quote, please contact us today.

Astrocyte Products

In vitro studies offer a great way to obtain cheap, fast, and replicable results for preclinical drug screenings and other research applications, especially in comparison to animal experiments. Creative Biolabs provides a comprehensive range of primary astrocytes, including mouse, rat, human, and iPSC-derived astrocyte cell lines.

Introduction

Astrocytes represent one of the most numerous and complex types of glial cells within the central nervous system (CNS). Astrocytes fulfill a multitude of functions within the nervous system. These include maintaining ion homeostasis, controlling the clearance and turnover of neurotransmitters, providing metabolic support, constructing the neurovascular barrier, shaping the neuro-glial-vascular unit, and regulating the formation and operation of the glymphatic system. Astrocyte function is implicated in the pathogenesis of various neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), and depression (MDD), and as a result are a focus for potential therapeutic targets.

Astrocyte Assays

• Neurons, Astrocytes and Microglia Co-culture Assay

The tri-culture system of neurons, astrocytes, and microglia offers a robust platform for neuroscience research, enabling the simulation of intricate in vivo environments and facilitating a comprehensive understanding of the interplay between neurons and glia and their involvement in diverse pathologies. This system is invaluable for elucidating the mechanisms of neurodegenerative diseases and neuroinflammation. Additionally, it is a powerful tool for drug screening and the development of new therapies.

• Astrocytosis Assay

Astrocytosis (also known as astrogliosis, reactive astrocytosis, or reactive astrogliosis) refers to a series of molecular, cellular and functional changes in astrocytes during CNS injury or disease. These changes typically manifest as astrocyte proliferation, morphological changes, and upregulation of glial fibrillary acid protein (GFAP) expression. In diseases such as AD, PD, the overactivity or dysfunction of astrocytes can contribute to disease exacerbation. Our system reliably triggers astrocytosis and tracks its development over time, making it a perfect model for testing novel therapeutic agents or for providing insights helpful for early diagnosis and disease assessment.

At Creative Biolabs, our astrocyte assays offer reliable and precise data for your research needs. We invite you to contact us to discuss your project plans in detail.