Spinal Muscular Atrophy (SMA) In Vitro Assay Services
Mutations in the SMN1 gene underlie spinal muscular atrophy (SMA), a genetic neurodegenerative condition characterized by motor neuron degeneration, leading to debilitating muscle weakness and atrophy. Despite the absence of a cure, recent advancements in gene therapy, drug discovery, and molecular analysis have yielded significant progress. Creative Biolabs provides a comprehensive suite of advanced in vitro, in vivo, and ex vivo assays, enabling researchers to precisely investigate the complex mechanisms driving SMA pathogenesis.
Available In Vitro Models
Fig.1 SMA induced Neurons.1
Cell models | Details |
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SMA Patient-Derived iPSCs |
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3D Tissue-Specific Spinal Cord Culture Model |
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Spinal Cord Organoid |
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Available SMA In Vitro Services
- Precise SMN Protein Quantification
We offer precise SMN protein quantification in peripheral blood mononuclear cells (PBCs) utilizing advanced imaging flow cytometry and electrochemiluminescence detection. This technology enables sensitive, semi-quantitative analysis, effectively distinguishing functional SMN protein levels. This provides a robust platform for real-time, dynamic monitoring of drug efficacy during SMA therapeutic development.
Our high-throughput phenotypic screening services offer a versatile suite of detection methods, including fluorescence, luminescence, and color readouts, to accelerate your SMA research. These technologies are adaptable for both array-based and pool-based screening strategies, such as FACS or NGS, and can be seamlessly integrated with cell immunophenotyping. This comprehensive approach ensures a thorough and efficient analysis, providing robust support for your SMA research endeavors.
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For further information regarding the products and services provided, project-specific consultation, and pricing, please submit an inquiry here.
Reference
- Sierra-Delgado, Julieth Andrea, et al. "In vitro modeling as a tool for testing therapeutics for spinal muscular atrophy and IGHMBP2-related disorders." Biology 12.6 (2023): 867. Distributed under Open Access license CC BY 4.0, without modification.
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