ALS In Vitro Assay
Creative Biolabs offers cutting-edge In Vitro Assay Services specifically tailored for ALS research, providing invaluable insights into the underlying mechanisms of the disease and potential therapeutic strategies.
Cell Models
Creative Biolabs offers a comprehensive range of In Vitro assay models tailored to address various aspects of ALS pathogenesis. Our model list includes:
| Cell Models | Details |
|---|---|
| Motor Neuron-Like Cell Lines |
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| Primary Motor Neuron Cultures |
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| Astrocyte and Glial Cell Cultures |
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| Organoids and 3D Cultures |
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ALS In Vitro Assays at Creative Biolabs
Our repertoire of ALS In Vitro assays includes a range of well-established protocols, each targeting distinct disease mechanisms. These assays are meticulously designed to provide quantitative readouts that enable precise evaluation of therapeutic interventions. Some of our featured assays include:
- Neurite length and branching: Measure the extension and complexity of motor neuron projections, reflecting neuronal development and function.
- Cell viability assays (MTT, CellTiter-Glo): Quantify the overall health and survival of motor neurons.
- Detection of protein aggregates: Quantify the presence of aggregated proteins, such as such as mutant SOD1, TDP-43, FUS and C9orf72.
- Subcellular localization: Assess the proper subcellular distribution of key ALS-associated proteins.
- Measurement of ROS levels: Evaluate the extent of oxidative stress in motor neurons.
- Mitochondrial membrane potential (Δψm): Assess mitochondrial health and function.
- Measurement of glutamate-induced excitotoxicity and calcium influx in motor neurons, enabling the identification of potential neuroprotective agents.
- Electrophysiological recordings: Study changes in membrane potential, ion channel activity, and neuronal excitability in motor neurons.
Creative Biolabs stands at the forefront of ALS research, offering cutting-edge In Vitro assay services that empower researchers to unravel the intricacies of ALS pathology, accelerate drug discovery, and ultimately bring us closer to effective treatments for this devastating disorder. Our commitment to scientific excellence and innovation drives us to deliver unparalleled support to advance the field of neurodegenerative disease research.
For inquiries and collaborations, please don't hesitate to contact us for more information.
