MS In Vitro Assay
Creative Biolabs provides comprehensive and groundbreaking in vitro assay solutions for Multiple Sclerosis (MS), enabling researchers to unravel the intricate mechanisms that underlie this complex neurological disorder.
In Vitro Models of MS at Creative Biolabs
At Creative Biolabs, we recognize the crucial role of cell models in replicating the intricate cellular environment of MS. Our vast array of well-established cell lines, including primary human neural cells, oligodendrocytes, and immune cells, accurately mimic the pathological conditions observed in MS patients.
T Cells
T cells play a central role in the immune response in MS. T-cell lines derived from patients with MS or healthy individuals, as well as primary T cells, are used to study the activation, differentiation, and interactions of T cells in MS.
B Cells
B cells contribute to the immune response and inflammation in MS. B-cell lines and primary B cells are utilized to investigate the role of B cells in the MS disease and explore potential.
Monocytes/Macrophages
These immune cells are involved in the inflammatory response in MS. Monocytic cell lines and primary monocytes/macrophages are used to study their interactions with other cells and their contributions to MS disease progression.
Dendritic Cells
Dendritic cells are important antigen-presenting cells that initiate and regulate immune responses. They are studied in MS research to understand their role in immune activation and tolerance.
Oligodendrocytes
These cells are responsible for producing myelin, the protective coating of nerve fibers. OPCs and oligodendrocytes are investigated to understand the mechanisms of demyelination and remyelination in MS.
Microglia
Microglia are resident immune cells of the central nervous system. They are implicated in neuroinflammation and tissue damage in MS. Researchers study microglia to elucidate their contributions to disease pathology.
Astrocytes
Astrocytes are supporting cells in the central nervous system. Their role in inflammation and tissue repair in MS is an active area of investigation.
Neural Stem Cells
Neural stem cells are explored for their potential to differentiate into various neural cell types, aiding in the regeneration and repair of damaged tissue in MS.
MS In Vitro Assays at Creative Biolabs
Our cutting-edge multiplex platforms allow for the precise quantification of cytokines, chemokines, and other immune mediators. This enables us to delineate the inflammatory milieu associated with MS and assess the impact of potential therapeutics on immune responses.
- Antigen Presentation Assays
These assays evaluate the ability of antigen-presenting cells to stimulate T-cell responses. They help researchers understand how immune cells recognize and respond to myelin antigens in MS.
Studying LPS-induced inflammation in MS-related immune cells can provide insights into the exaggerated immune responses and neuroinflammation observed in MS lesions. It can help researchers understand the mechanisms by which immune cells contribute to demyelination and neuronal damage in the context of inflammation.
Nitric oxide is a signaling molecule that plays a role in neuroinflammation and oxidative stress, which are key aspects of MS pathology. Measuring nitric oxide levels helps researchers understand the balance between its physiological and pathological roles in MS.
Preserving myelin sheaths is a fundamental therapeutic goal in MS. Through innovative myelination assays, we replicate the process of myelin formation using co-cultures of oligodendrocytes and neurons. This platform facilitates the screening of compounds that enhance myelination and promote neural repair.
- Myelin Phagocytosis Assay
These assays assess the ability of immune cells to phagocytose myelin, providing insights into the mechanisms of demyelination and potential therapeutic interventions.
Advantages of In Vitro Assay for MS at Creative Biolabs
Creative Biolabs' cutting-edge in vitro cell models play a pivotal role in facilitating neurotoxicity assessments and pharmaceutical screenings. Our versatile in vitro assays establish a robust framework for dissecting the intricate pathways of multiple sclerosis (MS) pathogenesis, pinpointing promising therapeutic targets, and appraising potential interventions.
With our regulatory expertise and extensive experience in neuroscience research, Creative Biolabs stands ready to propel your MS research endeavors to new heights. Please feel free to contact us for more details.
