- Tracer Type:
- Optogenetics
- Applications:
- Optogenetics
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Lot Number
SPECIFIC INQUIRY
inquiryDescription
The hEF1a promoter, cloned from the promoter region of human translation elongation factor 1A1 (eukaryotic translation elongation factor 1 alpha 1 (EEF1A1)), is 1.3 kb in length, expresses constitutively, and has no cell tissue specificity.
NpHR, a light-driven chloride ion pump, belongs to Halorhodopsin. The common version is NpHR3.0, which adds the endoplasmic reticulum forward transport signal and the Golgi transport signal to the cell membrane on the basis of NpHR, which improves its expression on the cell membrane and is the most commonly used photoinhibition tool. NpHR is usually driven by yellow light around 570nm and can be used simultaneously with hChR2 (H134R).
Tracer Type
Functional Gene
Activity
Serotype
Virus Type
Applications
Research Areas
Promoter
Expression
Fluorophore

Publications (0)
ExcellentWe used this vector for targeted inhibition in our mouse modelsThe hEF1a promoter ensured strong and ubiquitous expression across various cell types, and the fDIO system provided precise control over which cells were being manipulated. The fluorescence from the mCherry reporter was bright and easy to detect, which significantly facilitated our analysis.
ExcellentI have utilized the vector in several projects aimed at understanding neural circuitryThe viral vector delivered reliable and high levels of expression in the targeted neurons. The inclusion of the WPRE element seemed to enhance the stability and translation of the transgene, making our results very reproducible. The quality and consistency of this product have been outstanding.
ExcellentThis optogenetic tool has greatly facilitated our ability to control and study neuronal activityThe eNpHR 3.0 construct allowed for effective silencing of neural populations, and the mCherry reporter was incredibly helpful for confirming expression patterns. The vector's efficiency in transducing our cells of interest was remarkable, providing us with clear and interpretable data.
ExcellentThe overall performance and reliability of this product have been excellentIn our optogenetics studies, the AAV2/9-hEF1a-fDIO-eNpHR 3.0-mCherry-WPRE-pA vector has provided reliable and high-efficiency transduction.
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