Huntington's Disease (HD) Model based In Vitro Assay Services
Huntington's Disease (HD) is a devastating inherited neurodegenerative disorder stemming from mutations within the HTT gene. This gene, located on chromosome 4, provides the blueprint for the huntingtin protein, which is normally expressed in the brain. However, when the CAG repeat sequence within the HTT gene abnormally expands, it sets off a cascade of events leading to the abnormal accumulation of mutant huntingtin protein. This buildup ultimately triggers the progressive degeneration and death of nerve cells, resulting in the characteristic motor, cognitive, and psychiatric symptoms of HD. Our services encompass comprehensive in vitro, in vivo, and ex vivo assays to meet your specific needs. Furthermore, our services include personalized customization options, which can accelerate the development of neuropharmacology validation experiments, a critical component of HD research.
Available In Vitro Models
Fig.1 Characterizing GABAergic medium spiny-like neurons derived from human pluripotent stem cells (PSCs).1
Cell models | Details |
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iPSC-derived Neuronal Models |
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Reprogrammed Striatal Neuron Model |
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Coronal Tissue Organ Slice Model |
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Cell Line Models |
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Available HD In Vitro Services
Our CRO platform is committed to accelerating the development of HD treatments through relentless technological innovation and unparalleled service. We empower our clients with the efficiency and precision they need to make a difference.
mHTT Aggregation/Lowering Assay | HTT Splicing Assay |
Ready to accelerate your HD research? Our expert team and cutting-edge in vitro services can help you unlock new discoveries and advance the development of effective therapies. Contact us today to explore how our comprehensive platform can support your research goals.
Reference
- Nekrasov, Evgeny D., et al. "Manifestation of Huntington's disease pathology in human induced pluripotent stem cell-derived neurons." Molecular neurodegeneration 11 (2016): 1-15. Distributed under Open Access license CC BY 4.0, without modification.
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