Creative Biolabs

VSV-eGFP [Vesicular Stomatitis Virus (VSV)]

[CAT#: NTA-2011-ZP20]

Anterograde, multisynaptic

Tracer Type:
Virus Vector/Partical
Applications:
Neural Tracing

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Description
Vesicular stomatitis virus (VSV) is a non-segmented negative-strand RNA virus in the virus genus of the Rhabdoviridae family. The genome of VSV is approximately 11 kb-12 kb nucleotides, which encode nucleoprotein (N), phosphoprotein (P), matrix protein (M), glycoprotein (G) and large polymerase protein (L). Improved VSV has been widely used as an anterograde tracer.
Glycoprotein (G) is an important component of VSV anterograde synapse. When G (VSV-ΔG) is removed, it will lose the ability to cross synapses, but it can still express foreign genes in high abundance. Therefore, VSV-ΔG can be used to quickly obtain a complete image of neuron projection distribution, and can also be used for anterograde single synapse tracking.

Creative Biolabs has established a recombinant VSV platform based on our experienced employees and advanced molecular biology technology, and can provide VSV services to promote VSV-based neuron tracking research.

Applications
●Multi-synaptic tracking from the periphery to the center of the brain or from lower to higher brain regions.
●Track the neural network in the disease or injury model.
● Changes in neural networks during neural development.
Tracer Type
Virus Vector/Partical
Virus Type
Vesicular Stomatitis Virus (VSV)
Applications
Neural Tracing
Research Areas
Neural Circuit Mapping
Direction of Transport
Anterograde
Expression
Normal Expression
Fluorophore
EGFP
Storage
Please refer to the protocal.
Research Use Only
For research use only.
References
1. Hastie E, Grdzelishvili VZ. Vesicular stomatitis virus as a flexible platform for oncolytic virotherapy against cancer. J Gen Virol. 2012 Dec;93(Pt 12):2529-45.
2. Bishnoi, S., Tiwari, R., Gupta, S., Byrareddy, S.N., Nayak, D. Oncotargeting by Vesicular Stomatitis Virus (VSV): Advances in cancer therapy. Viruses. 2018; 10(2): 90.
3. Beier KT, Saunders A, Oldenburg IA, Miyamichi K, Akhtar N, Luo L, Whelan SP, Sabatini B, Cepko CL. Anterograde or retrograde transsynaptic labeling of CNS neurons with vesicular stomatitis virus vectors. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15414-9.
For Research Use Only. Not For Clinical Use.
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