Immune Cell Profiling Service for Neurological Disease Research
Partner with us to unlock the complexities of neurological diseases. Our neurobiology CRO services combine advanced technologies with personalized solutions, enabling a comprehensive analysis of immune mechanisms and the discovery of crucial therapeutic targets. We specialize in precise immune cell profiling, accurately mapping immune diversity within the central nervous system (CNS), and defining the specific immune response profiles in neuroinflammatory conditions. Leverage our expertise to build a robust scientific foundation for your targeted therapeutic strategies. For further information regarding the products and services provided, project-specific consultation, and pricing, please submit an inquiry here.
Our Immune Cell Profiling Service
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Our high-throughput single-cell analysis platform delivers unparalleled insights into immune cell dynamics. Leveraging advanced microfluidic single-cell separation and 5'-end transcriptome sequencing, we simultaneously profile the gene expression of thousands of individual immune cells. This comprehensive approach also integrates paired TCR/BCR sequencing, providing a complete picture of immune cell function and interaction. | Delve into the intricacies of T and B cell responses with our comprehensive TCR/BCR library analysis and antigen-specific T cell isolation services. Leveraging advanced single-cell sequencing, we precisely map clonal expansion and diversity, revealing critical immune response patterns. This level of detail is particularly powerful in dissecting complex neuroinflammatory diseases like multiple sclerosis (MS), providing essential insights for targeted therapeutic development. |
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We specialize in CNS-specific sample processing and multi-omics integration, enabling a comprehensive view of neuroimmune interactions. Our services support detailed immune cell analysis across cerebrospinal fluid (CSF), peripheral blood mononuclear cells (PBMC), and humanized mouse models. By meticulously correlating local and systemic immune responses within the central nervous system, we provide a holistic understanding crucial for advancing neurological disease research. | Our bioinformatics and translational medicine support services provide tailored analytical solutions to accelerate your research. We offer customized bioinformatics analysis, including precise cell subpopulation annotation using authoritative databases like CellMarker and PanglaoDB, detailed clone trajectory tracking, and comprehensive differential gene pathway enrichment. These services are designed to translate complex data into actionable insights, bridging the gap between discovery and clinical application. |
Immune Profiling Service Options
Immuno-Profiling for bulk repertoire analysis | Single-Cell Immuno-Profiling for physical pairing of chains | |
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BCR sequencing (VH and VL chains) | Yes | Yes |
TCR Sequencing (α and β chains) | Yes | Yes |
Starting materials | Total RNA, Blood, Cell pellet, Tissue, CSF | Cell suspension |
V(D)J amplification method | Proprietary 5′ RACE | Targeted enrichment of cDNA with cell-specified barcodes |
Physical pairing of VH/VL or α/β chains | No | Yes |
Workflow
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- Mouse Glioma Cell Line GL-261-Luc (Cat#: NCL-2108P06)
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- Lenti of Human TAR DNA binding protein (TARDBP) (NM_007375) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0832)
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- App Rat amyloid beta (A4) precursor protein (App)(NM_019288) ORF clone, Untagged (Cat#: NEP-0421-R0053)
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- NeuroBiologics™ Pig Cerebrospinal Fluid (Cat#: NRZP-0822-ZP498)
- NeuroBiologics™ Human Cerebrospinal Fluid (Cat#: NRZP-0822-ZP491)
- NeuroBiologics™ Monkey Cerebrospinal Fluid (Cat#: NRZP-0822-ZP495)
- NeuroBiologics™ Rat Cerebrospinal Fluid (Cat#: NRZP-0822-ZP496)
- NeuroBiologics™ Mouse Cerebrospinal Fluid (Cat#: NRZP-0822-ZP497)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP502)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP509)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP498)
- NeuroPro™ Anti-Erythropoietin BBB Shuttle Protein (Cat#: NRZP-0423-ZP499)
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