Immune Cell Profiling Service

Partner with us to unlock the complexities of neurological diseases. Our neurobiology CRO services combine advanced technologies with personalized solutions, enabling a comprehensive analysis of immune mechanisms and the discovery of crucial therapeutic targets. We specialize in precise immune cell profiling, accurately mapping immune diversity within the central nervous system (CNS), and defining the specific immune response profiles in neuroinflammatory conditions. Leverage our expertise to build a robust scientific foundation for your targeted therapeutic strategies. For further information regarding the products and services provided, project-specific consultation, and pricing, please submit an inquiry here.

Our Immune Cell Profiling Service

High-Throughput Single-Cell Analysis	TCR/BCR Library Analysis and Antigen-Specific T Cell Isolation
Our high-throughput single-cell analysis platform delivers unparalleled insights into immune cell dynamics. Leveraging advanced microfluidic single-cell separation and 5'-end transcriptome sequencing, we simultaneously profile the gene expression of thousands of individual immune cells. This comprehensive approach also integrates paired TCR/BCR sequencing, providing a complete picture of immune cell function and interaction.	Delve into the intricacies of T and B cell responses with our comprehensive TCR/BCR library analysis and antigen-specific T cell isolation services. Leveraging advanced single-cell sequencing, we precisely map clonal expansion and diversity, revealing critical immune response patterns. This level of detail is particularly powerful in dissecting complex neuroinflammatory diseases like multiple sclerosis (MS), providing essential insights for targeted therapeutic development.
CNS-Specific Sample Processing and Multi-Omics Integration	Bioinformatics and Translational Medicine Support
We specialize in CNS-specific sample processing and multi-omics integration, enabling a comprehensive view of neuroimmune interactions. Our services support detailed immune cell analysis across cerebrospinal fluid (CSF), peripheral blood mononuclear cells (PBMC), and humanized mouse models. By meticulously correlating local and systemic immune responses within the central nervous system, we provide a holistic understanding crucial for advancing neurological disease research.	Our bioinformatics and translational medicine support services provide tailored analytical solutions to accelerate your research. We offer customized bioinformatics analysis, including precise cell subpopulation annotation using authoritative databases like CellMarker and PanglaoDB, detailed clone trajectory tracking, and comprehensive differential gene pathway enrichment. These services are designed to translate complex data into actionable insights, bridging the gap between discovery and clinical application.

Immune Profiling Service Options

	Immuno-Profiling for bulk repertoire analysis	Single-Cell Immuno-Profiling for physical pairing of chains
BCR sequencing (VH and VL chains)	Yes	Yes
TCR Sequencing (α and β chains)	Yes	Yes
Starting materials	Total RNA, Blood, Cell pellet, Tissue, CSF	Cell suspension
V(D)J amplification method	Proprietary 5′ RACE	Targeted enrichment of cDNA with cell-specified barcodes
Physical pairing of VH/VL or α/β chains	No	Yes

Workflow

Fig.1 Workflow of immune cell profiling service. (Creative Biolabs Original)

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