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Creative Biolabs
Product

NeuroMab™ Anti-EPHA2 BBB Shuttle Antibody,Clone NR2607P

[CAT#: NRZP-1022-ZP3864]

Host Species:
Mouse
Species Reactivity:
Human
Applications:
WB

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Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Clone Number

NR2607P

Applications

WB

Relevant Diseases

Glioblastoma Multiforme
Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only
Target

Target

EPHA2

Official Name

EPHA2

Full Name

EPH receptor A2 (ephrin type-A receptor 2)

Alternative Names

EPHA2; Epha2; AW545284; Eck; Myk2; Sek-2; Sek2; ARCC2; CTPA; CTPP1; CTRCT6; EPH receptor A2; ECK
Product Pictures
WB

Figure 1A is a graph showing the results of Western blotting showing whether an anti-EPHA2 antibody induces phosphorylation activity of EPHA2 tyrosine residues.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1A is a graph showing the results in the absence of a cross-linked antibody. The upper bar shows the results for the 4G10 antibody, and the lower bar shows the results for the anti-EPHA2 antibody (D7).

WB

Figure 1B is a graph showing the Western blotting results of the presence or absence of the phosphorylation activity of EPHA2 tyrosine residues induced by anti-EPHA2 antibodies.

Fig. 1B is a graph showing the results in the presence of cross-linked antibodies, the upper part is the result of 4G10 antibody, and the lower part is the result of anti-EPHA2 antibody (D7).

WB

Figure 2A is a graph showing the results of Western blot showing whether an anti-EPHA2 antibody has the activity of inducing a decrease in EPHA2 protein level.

Figure 2A is a graph representing the results obtained in the absence of cross-linked antibodies, wherein the upper column represents the results for the anti-EPHA2 antibody (D7) and the lower column represents the results for the anti-β-actin antibody.

WB

Figure 2B is a graph showing the results of Western blot showing whether the anti-EPHA2 antibody has the activity of inducing the decrease of EPHA2 protein level.

Figure 2B is a graph showing the results in the presence of a cross-linked antibody, the upper column represents the results for the anti-EPHA2 antibody (D7), and the lower column represents the results for the anti-β-actin antibody;

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For Research Use Only. Not For Clinical Use.
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