NeuroMab™ Anti-EPHA2 BBB Shuttle Antibody(NRZP-1022-ZP3870)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

ELISA

Relevant Diseases

Glioblastoma Multiforme

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

EPHA2

Official Name

EPHA2

Full Name

EPH receptor A2 (ephrin type-A receptor 2)

Alternative Names

EPHA2; Epha2; AW545284; Eck; Myk2; Sek-2; Sek2; ARCC2; CTPA; CTPP1; CTRCT6; EPH receptor A2; ECK

Product Pictures

ELISA

Figure 1 shows the reactivity when SHM41, 57-1 or 230-1 was used as supplementary antibody and biotin-labeled 57-1 or 230-1 was used as detection antibody.

ELISA

Figure 2 is an amino acid sequence diagram of the CDRs of the mouse anti-EPHA2 monoclonal antibody 230-1.

ELISA

Figure 3 shows the amino acid sequence of the CDRs of the mouse anti-EPHA2 monoclonal antibody 57-1.

ELISA

Figure 4 shows the reactivity of the ELISA system to EPHA2 (supplementary antibody 230-1 and detection antibody biotinylated 57-1, supplementary antibody 57-1 and detection antibody biotinylated 230-1).