NeuroMab™ Anti-HMGB1 Antibody,Clone NR2668P
- Host Species:
- Human
- Species Reactivity:
- Human; Mouse
- Applications:
- Block; Inhib; In Vitro; In Vivo
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inquirySpecies Reactivity
Clonality
Host Species
Clone Number
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Relevant Diseases
Preservatives
Concentration
Endotoxin Level
Low Endotoxin < 1 EU/mg
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Research Use Only
Figure 1 Binding kinetics and specificity of human anti-HMG1 antibodies.
HMG1 capture ELISA binding curves of several human anti-HMG1 antibodies demonstrate that these antibodies have different affinities for recombinant HMG1 produced in E. coli.
Figure 2 A number of human anti-HMG1 antibodies inhibited HMG1-stimulated cytokine release from human PBMCs.
Figure 3 Several human anti-HMG1 antibodies inhibit HMG1-stimulated cytokine gene expression in mouse macrophages (mMO).
Figure 4. A subset of human anti-HMG1 antibodies block the binding of recombinant HMG1 to RAGE.
Figure 5 Inhibitory effect of recombinant HMG1 on Thp-1 cells.
Representative dose response curves showing inhibition of recombinant HMG1 binding to Thp-1 cells by E11, G2 and a RAGE-Fc fusion protein are shown.
Figure 6 Human anti-HMG1 antibody is protective in a mouse model of acute lung injury (ALI).
Total cells recovered in BAL fluid from ALI mice treated with either G4 or E11 were reduced nearly 40% as compared to mice treated with either an isotype control antibody (R347). Treatment with an HMG1 A-box-Fc fusion protein only reduced total cells recovered by 23%.
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