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Creative Biolabs
Product

NeuroMab™ Anti-IFN Gamma Antibody,Clone NR3453P

[CAT#: NRP-0422-P1410]

Functional antibody against Human IFN Gamma

Host Species:
Human
Species Reactivity:
Human
Applications:
Block; Neut; Inhib; FC; In Vivo; In Vitro

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Product Overview

Description

The antibody binds to human interferon gamma (hIFNγ), thereby modulating the interaction between IFNγ and its receptor, IFNγ-R, and/or modulating the biological activities of IFNγ. The anti-IFNγ antibodies can be used in the prevention or treatment of immune-related disorders and in the amelioration of a symptom associated with an immune-related disorder.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Human

Clone Number

NR3453P

Applications

Block; Neut; Inhib; FC; In Vivo; In Vitro

Relevant Diseases

Neuroinflammation
Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

>95% by SDS PAGE or HPLC

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only
Target

Target

IFNGamma

Official Name

interferon gamma

Alternative Names

Interferon_gammaIPR002069interferon-gamma
Product Pictures
FuncS

Figure 1 is a graph depicting the affinity of the NI-0501 huIFNγ antibody for human IFNγ.

FuncS

Figure 2 is a graph comparing antibody activity produced by clones A6 and NI-0501 (also referred to herein as "A6 backmutated to germline" or "backmutated A6") clones.

FuncS

Figure 3 is a graph depicting the activity of the NI-0501 huIFNγ antibody against native human IFNγ.

FuncS

Figure 4 is a series of graphs depicting the binding of NI-0501 huIFNy antibody to recombinant IFNy from different species.

FuncS

Figure 5 is a graph depicting the ability of NI-0501 huIFNγ antibody to neutralize MHC class II upregulation induced by native macaque IFNγ.

Block

Figure 6 is a graph depicting the ability of the NI-0501 huIFNγ antibody to block IFNγ-induced IP-10 production in whole blood.

Publications

Publications (0)

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For Research Use Only. Not For Clinical Use.
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