NeuroMab™ Anti-IFN Gamma BBB Shuttle Antibody(NRZP-1022-ZP2821)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Human

Applications

Neut; Inhib

Relevant Diseases

Neuroinflammation

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

IFNGamma

Official Name

IFNG

Full Name

IFN gamma

Alternative Names

GD2

Product Pictures

Neut

Figure 2 contains graphs showing neutralization or inhibition of IFN-γ bioactivity by 1119, 1118 and 1121 monoclonal antibodies in a THP-1/HLA DR bioassay.

Neut

Figure 3 contains graphs showing that the 1119 monoclonal antibody neutralizes or inhibits the biological activity of IFN-γ in a whole blood bioassay (two donors).

Publications