NeuroMab™ Anti-IGF1R Antibody, Clone Al2
Functional antibody against Human IGF1R
- Host Species:
- Human
- Species Reactivity:
- Human
- Applications:
- Inhib; In Vivo; In Vitro
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Endotoxin Level
Low Endotoxin < 1 EU/mg
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Research Use Only
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Figure 1 shows the results of an assay measuring the ability of antibodies 2F8 and A12 to block the binding of IGF-I to immobilized soluble IGF-IR. A12 antibodies with kappa or lambda light chain constant regions were tested.
Figure 2 shows IGF-I-mediated inhibition of receptor phosphorylation.
Inhibitory effect of antibodies A12 and 2F8 on MCF7 breast cancer cells.
Figure 3 shows the inhibition of IGF-I mediated phosphorylation of downstream effector molecules by antibodies A12 and 2F8.
Figure 4 shows receptor internalization.
The figure shows the degradation of total cellular IGF-IR after chronic treatment with Al2.
Figure 5 shows receptor internalization.
Figure 6 shows the effect of antibody A12 on 3H-thymidine incorporation in a mitotic assay.
Figure 7 shows the results of an assay measuring the ability of antibodies 2F8 and A12 (λ light chain) to block IGF-I binding to MCF7 cells.
Figure 8 shows the results of an assay measuring the ability of antibodies 2F8 and A12 to block insulin binding to ZR75-I cells.
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