NeuroMab™ Anti-IGF1R Antibody, Clone KM1468

Figure 1 shows the reactivity of an anti-hIGF rat monoclonal antibody to hIGF-I with its native three-dimensional structure in a liquid system (competitive ELISA).

Figure 2 shows the effect of anti-hIGF antibodies KM1468, smi.2 and S1F2 on the growth of human breast cancer cell line MCF7 by hIGF and human insulin. A shows the cell growth activity of each factor.

Figure 3 shows the effect of anti-hIGF antibody KM14 68 , smi. Figure 2 and S1F2 after growth of the human colon cancer cell line HT-29 in the presence of hIGF and human insulin.

Figure 4 shows the cytostatic effect of KM1468 on hIGF-I expressing cells.

Dashed lines indicate the growth of A549/hIGF-I cells in the absence of anti-hIGF antibody KM1468, while solid lines indicate the growth of A549 cells in the absence of anti-hIGF antibody KM1468. ^ shows the growth of A549/hIGF-1 cells in the presence of anti-hIGF antibody KM1468, O shows the growth of A549 cells in the presence of anti-hIGF antibody KM1468.

Figure 5 is a graph showing the anti-tumor effect of anti-hIGF antibody KM1468.

The abscissa indicates the number of days after tumor transplantation, and the ordinate indicates the tumor volume.

Figure 6 shows the responses of anti-hIGF rat antibody KM1468 and anti-hIGF chimeric antibody KM3002 to hIGF-I.

Figure 7 shows the effect of anti-hIGF antibodies KM1468, sml.2, S1F2 and anti-hIGF chimeric antibody KM3002 on the growth of human colon cancer cell line HT-29 by hIGF.