NeuroMab™ Anti-IGF1R BBB Shuttle Antibody, Clone Al2
- Host Species:
- Human
- Species Reactivity:
- Human
- Applications:
- Inhib; In Vivo; In Vitro
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Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
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Figure 1 shows the results of an assay measuring the ability of antibodies 2F8 and A12 to block the binding of IGF-I to immobilized soluble IGF-IR. A12 antibodies with kappa or lambda light chain constant regions were tested.
Figure 2 shows IGF-I mediated inhibition of receptor phosphorylation.
Inhibition in MCF7 breast cancer cells by antibodies Al2 and 2F8.
Figure 3 shows the inhibition of IGF-I mediated phosphorylation of downstream effector molecules by antibodies A12 and 2F8.
Figure 4 shows receptor internalization.
The figure shows degradation of total cellular IGF-IR after prolonged treatment with Al2.
Figure 5 shows receptor internalization.
Figure 6 shows the effect of antibody A12 on 3H-thymidine incorporation in a mitotic assay.
Figure 7 shows the results of an assay measuring the ability of antibodies 2F8 and A12 (lambda light chain) to block the binding of IGF-I to MCF7 cells.
Figure 8 shows the results of an assay to determine the ability of antibodies 2F8 and A12 to block insulin binding to ZR75-I cells.
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