NeuroMab™ Anti-IGF1R BBB Shuttle Antibody, Clone I-3466
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- FC; Inhib; In Vivo; In Vitro
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Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
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Figure 1 Competition of [125I]-IGF-1 binding to IGF-IR by monoclonal antibody I-3466.
Specific [125I]-IGF-1 binding (in %) was plotted as a function of ligand concentration on a semilog graph. Specific binding values are the means of experiments performed in triplicate.
Figure 2 [125I]-IGF-2 competes with mAb I-3466 for binding to IGF-IR.
Figure 3 Effect of I-3466 Mab on IGF2-induced phosphorylation of IGF-IR β-chain in MCF-7 cells.
Figure 4 In vivo activity of I-3466 in the DU145 xenograft tumor model.
Figure 5 Sensorgrams of the association and dissociation phases of IgG1 humanized I-3466/hIGF-IR-ECD complexes in five different concentrations of hIGF-IR-ECD.
Figure 6 Effect of I-3466 antibody on IGF1-induced growth of MCF-7 in vitro.
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