Product
NeuroMab™ Anti-EPHA2 BBB Shuttle Antibody,Clone NR898P
[CAT#: NRZP-1022-ZP3873]
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- Inhib; In Vitro; Agonist
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Mouse
Clone Number
NR898P
Applications
Inhib; In Vitro; Agonist
Relevant Diseases
Glioblastoma Multiforme
Product Properties
Storage
Store at -20°C. Do not aliquot the antibody.
Research Use Only
For research use only
Target
Target
EPHA2
Official Name
EPHA2
Full Name
EPH receptor A2 (ephrin type-A receptor 2)
Alternative Names
EPHA2; Epha2; AW545284; Eck; Myk2; Sek-2; Sek2; ARCC2; CTPA; CTPP1; CTRCT6; EPH receptor A2; ECK
Product Pictures
Figure 1 Isothermal titration calorimetry (ITC) curves of binding between 135G3 and EphA2-LBD (AH = -21.9 kcal/mol, -TAS = 13.5 kcal/mol) and EphA4-LBD (no significant binding).
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Figure 2 EphA2 receptor phosphorylation assay of different doses of YSA, 123B9 and 135G3 in HEK293 cells.
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Figure 3 Comparison of DELFIA shift dose response curves of 123B9, 135G3 and 135H11
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Figure 4 135H12 is a potent agonist compared to the EphA2 agonistic monomer.
Publications
Publications (0)
Neural Cell Lines
Kits
Neural Antibodies
For Research Use Only. Not For Clinical Use.
